PP1γ Activators
Common PP1γ Activators include, but are not limited to Okadaic Acid CAS 78111-17-8, Calyculin A CAS 101932-71-2, Tautomycin from Streptomyces spiroverticillatus CAS 109946-35-2, Cantharidin CAS 56-25-7 and Endothall CAS 145-73-3.
Protein Phosphatase 1 gamma (PP1γ) belongs to the protein phosphatase 1 (PP1) family, a group of serine/threonine phosphatases that are pivotal in modulating various cellular processes by dephosphorylating target proteins. Phosphorylation and dephosphorylation serve as essential post-translational modifications, acting as molecular switches that regulate protein function, localization, and interactions. PP1γ, one of the isoforms of the PP1 family, is intricately involved in a myriad of cellular pathways, including cell cycle progression, muscle contraction, neuronal signaling, and glycogen metabolism. Its specific role often depends on its interaction with various regulatory subunits, which confer substrate specificity and modulate its phosphatase activity. By regulating the phosphorylation status of its target proteins, PP1γ plays an instrumental role in ensuring cellular homeostasis and functional integrity.
Activators of PP1γ are molecules or compounds that enhance the expression, stability, or phosphatase activity of PP1γ. These activators may function by promoting the transcription or translation of the PP1γ gene, stabilizing the protein's conformation, or increasing its catalytic efficiency in dephosphorylating target substrates. The presence of PP1γ activators can profoundly influence the dynamics of intracellular signaling pathways, modulating the outcomes of various cellular processes governed by serine/threonine phosphorylation. Delving into the realm of PP1γ activators offers a window into the complex world of protein phosphorylation, highlighting the delicate balance that shapes cellular responses. As the tapestry of cell signaling continues to be unraveled, the role of PP1γ and its activators emerges as a central narrative, elucidating the intricate molecular dance that underpins cellular behavior and adaptation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $48.00 $199.00 | 1 | |
Known to inhibit protein phosphatases, potentially influencing PP1γ indirectly. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $260.00 | 9 | |
Inhibits PP2A more than PP1, but might still influence the PP1 family indirectly. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase inhibitor which may have effects on protein phosphatase activity and expression. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Has been shown to inhibit protein phosphatase 2C, and might have effects on PP1γ. | ||||||
D-O-Phospho Threonine | 96193-69-0 | sc-211184 | 10 mg | $360.00 | ||
As a post-translational modification, it's a substrate for phosphatases and could indirectly modulate PP1γ. | ||||||