PP1γ Inhibitors
Common PP1γ Inhibitors include, but are not limited to Okadaic Acid CAS 78111-17-8, Cantharidin CAS 56-25-7, Tautomycin from Streptomyces spiroverticillatus CAS 109946-35-2, Calyculin A CAS 101932-71-2 and Salubrinal CAS 405060-95-9.
PP1γ inhibitors belong to a distinct chemical class designed to interact with protein phosphatase 1 gamma (PP1γ), a vital enzyme that plays a pivotal role in the dephosphorylation of a wide range of cellular proteins. This enzymatic process of dephosphorylation is essential for regulating various cellular signaling pathways, controlling cellular growth, metabolism, and differentiation. Inhibitors within this class are engineered to selectively target and modulate the activity of PP1γ, offering researchers a tool to dissect the intricate dynamics of cellular signaling networks. Through the manipulation of PP1γ function, these inhibitors contribute to a deeper understanding of cellular processes and the underlying molecular mechanisms that drive cellular responses.
The study of PP1γ inhibitors is undertaken to unravel the complexities of protein dephosphorylation and its impact on cellular functions. By investigating the effects of PP1γ inhibitors on dephosphorylation events, researchers aim to uncover novel insights into the regulation of cellular pathways and identify points of intervention for future studies. This chemical class provides a means to explore the underlying molecular processes that drive cellular responses, contributing to the advancement of fundamental biological knowledge and opening new avenues for scientific inquiry.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent and selective inhibitor of PPP1CC. It irreversibly inhibits the activity of PP1 by binding to the catalytic subunit. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
Cantharidin is a natural compound found in blister beetles that has been shown to inhibit PPP1CC activity. It acts as a potent and reversible inhibitor of PP1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a marine toxin that inhibits PPP1CC by interacting with the catalytic subunit and blocking its activity. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal is a selective inhibitor of PPP1CC involved in endoplasmic reticulum (ER) stress response. It inhibits the dephosphorylation of eukaryotic translation initiation factor 2-alpha (eIF2α) by PP1. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506 is an immunosuppressive drug that indirectly inhibits PPP1CC. It forms a complex with FK506-binding protein (FKBP), which then binds and inhibits the phosphatase activity of PP1. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that indirectly inhibits PPP1CC. It binds to cyclophilins and forms a complex that inhibits the phosphatase activity of PP1. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Combretastatin A-4 is a natural compound that has been reported to inhibit PPP1CC. It interferes with microtubule assembly and disrupts PP1 function. | ||||||