Popeye 2 Inhibitors
Chemical inhibitors of Popeye 2 can interfere with essential signaling pathways and cellular processes that regulate its function, particularly in cardiac muscle cells. Gö6976, for example, targets protein kinase C (PKC), a critical component in the signaling cascades that affect the involvement of Popeye 2 in cardiac function and protection against heart failure. By inhibiting PKC, Gö6976 disrupts the intracellular signals, thus potentially impairing Popeye 2 activity. Similarly, Chelerythrine and Bisindolylmaleimide I, both specific PKC inhibitors, can lead to a functional inhibition of Popeye 2 by dampening the PKC-mediated pathways that Popeye 2 is known to participate in within cardiac muscle tissues.
KN-93 inhibits the Ca2+/calmodulin-dependent protein kinase II (CaMKII), which has a role in calcium signaling pathways that influence Popeye 2 activity. By inhibiting CaMKII, KN-93 can attenuate the calcium-dependent processes central to Popeye 2's function. ML-7 targets myosin light chain kinase (MLCK), a kinase that influences muscle contraction, and by extension, could impede Popeye 2's role in muscle function. Furthermore, Y-27632, a ROCK inhibitor, and SB203580, a p38 MAP kinase inhibitor, are involved in modulating stress and inflammation pathways. Since Popeye 2 is implicated in the stress response of cardiac tissues, these inhibitors can impede Popeye 2's involvement in these responses. U73122 disrupts phospholipase C (PLC) activity, which is upstream of PKC, affecting signaling pathways involving Popeye 2. Additionally, W-7, as a calmodulin antagonist, disrupts Ca2+/calmodulin-dependent signaling, thus affecting Popeye 2 activity. Lastly, Genistein, by broadly inhibiting tyrosine kinases, can disrupt multiple signaling pathways, which can impair the functional role of Popeye 2 in cardiac muscle cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö6976 is a potent inhibitor of protein kinase C (PKC), which plays a role in regulating cardiac muscle contractility and protection against heart failure, processes in which Popeye 2 is involved. Inhibition of PKC can disrupt the intracellular signaling cascade, leading to a reduction in Popeye 2 activity related to these cardiac processes. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Popeye 2 is known to interact with cAMP signaling which is also sensitive to Ca2+ levels. By inhibiting CaMKII, KN-93 reduces Ca2+-dependent signaling pathways, potentially inhibiting the functional role of Popeye 2 in cardiac myocyte function and stress response. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent inhibitor of protein kinase A (PKA). Popeye 2 is implicated in cAMP-mediated signaling pathways which are regulated by PKA. Inhibition of PKA by H-89 could therefore inhibit Popeye 2's role in modulating this pathway and its downstream cardiac functions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). Since Popeye 2 is involved in the modulation of muscle contraction, inhibition of MLCK by ML-7 can disrupt the intracellular processes in which Popeye 2 participates, particularly affecting muscle function and contractility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). Popeye 2 has been associated with stress-mediated signaling pathways in cardiac tissue, which can be influenced by Rho/ROCK signaling. Thus, Y-27632 can inhibit Popeye 2 activity by altering the Rho/ROCK pathway and its associated cellular responses. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which is involved in response to stress and inflammation. Popeye 2 is also implicated in stress response in cardiac tissues, and thus, inhibition of p38 MAP kinase by SB203580 could inhibit the role of Popeye 2 in these processes. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 is a calmodulin antagonist, which by inhibiting calmodulin, can disrupt the Ca2+/calmodulin-dependent signaling pathways. Popeye 2, being sensitive to cAMP and Ca2+ signaling, could be functionally inhibited due to the disruption of these pathways by W-7. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a potent inhibitor of PKC. Because Popeye 2's activity is modulated via PKC-related pathways in cardiac muscle, inhibition of this kinase by chelerythrine can lead to decreased Popeye 2 activity, affecting heart muscle contractility and response to stress. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. It would functionally inhibit Popeye 2 by reducing PKC-mediated signaling, thereby affecting the pathways that Popeye 2 is known to participate in within the cardiac muscle and its protective roles. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, and while it is less specific, it can inhibit a range of tyrosine kinases that are involved in cell signaling pathways. Popeye 2's role in heart muscle function could be indirectly inhibited by genistein through the broad inhibition of these kinases, thereby affecting signaling processes in which Popeye 2 is involved. | ||||||