POLR3D Activators
RNA polymerase III subunit D (POLR3D) is an integral component of RNA polymerase III, the enzyme complex responsible for the synthesis of small, non-coding RNAs in eukaryotic cells. The gene that encodes for this protein is also referred to as POLR3D. POLR3D serves as one of the 17 subunits that constitute the RNA polymerase III complex, which is tasked with transcribing genes such as 5S rRNA, tRNA, and other small RNAs that play vital roles in the regulation of gene expression and the maintenance of cellular function.
POLR3D specifically is part of the core assembly of RNA polymerase III, contributing to the structural and functional stability of the complex. Its interactions within the polymerase are essential for the accurate initiation and elongation phases of transcription. The subunit is also believed to participate in the intricate processes that govern the recognition of promoter regions on DNA, ensuring that RNA polymerase III reliably targets the correct genes for transcription.Mutations in the POLR3D gene have been linked to rare and severe disorders, reflecting the critical nature of its role in cellular biology. These disorders are often characterized by defects in brain development and function, demonstrating the importance of POLR3D in the central nervous system. Additionally, given the fundamental necessity of the small RNAs synthesized by RNA polymerase III in various cellular processes, including protein synthesis and RNA splicing, POLR3D's involvement in health and disease is broad and significant.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin, a potent inhibitor of RNA polymerases II and III, can indirectly influence POLR3D by altering transcriptional dynamics and potentially compensatory mechanisms in the cell. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA synthesis, potentially affecting POLR3D activity indirectly through transcriptional regulation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA Polymerase II, which could lead to compensatory changes in RNA Polymerase III activity and indirectly affect POLR3D. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits RNA Polymerase II and III, potentially influencing POLR3D activity indirectly by altering global transcriptional processes. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $99.00 | 5 | |
Cordycepin, an adenosine analog, can inhibit RNA synthesis, potentially impacting POLR3D activity indirectly through effects on transcriptional regulation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin causes DNA cross-linking, which can indirectly affect POLR3D activity by altering the transcriptional accessibility of DNA. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
By inhibiting nuclear export, Leptomycin B could indirectly influence POLR3D by altering the distribution and availability of transcription factors and RNA molecules. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
This proteasome inhibitor might indirectly affect POLR3D by stabilizing proteins that regulate transcription, potentially influencing RNA Polymerase III activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A affects chromatin remodeling, potentially impacting POLR3D activity through changes in transcriptional regulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can alter gene expression patterns, potentially affecting POLR3D activity indirectly through epigenetic modifications. | ||||||