Podocin Activators
Podocin activators are compounds that target and enhance the function of podocin, a protein that is crucial for the structure and function of podocytes, which are specialized cells in the kidney that play a vital role in the filtration of blood into urine. Podocin is a membrane-associated protein that is a key component of the slit diaphragm, a structure connecting podocyte foot processes and serving as a selective filtration barrier in the glomerulus of the kidney. The integrity of the slit diaphragm is central to the proper functioning of the kidney's filtering units. Podocin itself acts as a scaffold protein, organizing and stabilizing the slit diaphragm complex, and interact with various other proteins to maintain the filtration barrier and podocyte architecture.
Podocin activators function by binding to podocin and increasing its stability or enhancing its interaction with other proteins within the slit diaphragm complex. By doing so, these activators can bolster the structural integrity of the slit diaphragm and support the maintenance of the filtration barrier. The action of podocin activators is highly specific as they interact with particular motifs or domains of the podocin protein, leading to changes in its conformation or its affinity for other proteins within the podocyte. This specificity is essential for the selective modulation of podocin without affecting the function of other proteins unintentionally.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan is an angiotensin II receptor antagonist. It may impact the renin-angiotensin-aldosterone system, potentially influencing podocyte function and glomerular health. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone is a mineralocorticoid receptor antagonist. Its influence on aldosterone pathways could indirectly affect podocyte function and the glomerular filtration barrier. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
Statins can impact cholesterol levels and have been associated with renal protective effects. Their influence on lipid metabolism and anti-inflammatory properties may contribute to podocyte health. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone is a peroxisome proliferator-activated receptor-gamma (PPARγ) agonist. Its potential effects on inflammation and oxidative stress may indirectly influence podocyte function. | ||||||
Pentoxifylline | 6493-05-6 | sc-203184 | 1 g | $20.00 | 3 | |
Pentoxifylline has anti-inflammatory properties and may influence cytokine production. Its impact on inflammation could potentially affect podocyte function and glomerular health. | ||||||
Tolvaptan | 150683-30-0 | sc-364638 sc-364638A | 10 mg 50 mg | $125.00 $624.00 | ||
Tolvaptan is a vasopressin V2 receptor antagonist. Its influence on water balance and aquaporin channels may indirectly affect podocyte function and glomerular health. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
Pirfenidone has anti-fibrotic and anti-inflammatory properties. Its potential impact on fibrosis and inflammation could indirectly influence podocyte function and glomerular health. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
Bardoxolone methyl has anti-inflammatory and antioxidant properties. Its influence on oxidative stress and inflammation may contribute to potential effects on podocyte function and kidney health. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $47.00 $94.00 $151.00 | 6 | |
Candesartan is an angiotensin II receptor antagonist. Its potential influence on the renin-angiotensin-aldosterone system may impact podocyte function and contribute to glomerular health. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA, an omega-3 fatty acid, has anti-inflammatory and lipid-modifying effects. Its potential impact on inflammation and lipid metabolism may indirectly influence podocyte function and glomerular health. | ||||||