Podocin Inhibitors
Podocin inhibitors comprise a diverse group of chemicals targeting various signaling pathways vital for podocyte structure and function. The mTOR inhibitor AZD8055 directly impacts the PI3K/Akt/mTOR pathway, crucial for maintaining podocyte integrity. Smilagenin, a saponin, indirectly influences Podocin by inhibiting NF-κB signaling, mitigating inflammatory responses linked to podocyte dysfunction. dSrc kinase inhibitor PP2 stabilizes podocyte foot processes by affecting actin cytoskeleton dynamics. A769662, an AMPK activator, indirectly modulates Podocin by promoting AMPK activation, influencing cellular metabolism and stress responses essential for podocyte health. SB-216763, a GSK-3β inhibitor, indirectly affects Podocin through Wnt signaling modulation, critical for podocyte structure maintenance.
Cucurbitacin I, a JAK/STAT pathway inhibitor, impacts cytokine signaling and immune responses, potentially influencing Podocin by regulating inflammatory processes related to podocyte health. YM-254890, a Gαq/11 inhibitor, indirectly affects Podocin by influencing intracellular calcium signaling, crucial for various cellular processes, including podocyte function. Rapamycin, an mTOR inhibitor, and LY294002, a PI3K inhibitor, both impact the Akt/mTOR pathway, regulating key signaling cascades involved in podocyte function. U0126, a MEK inhibitor, influences the MAPK pathway, crucial for cellular responses and maintenance of podocyte structure. Fingolimod, an S1P receptor modulator, indirectly affects podocyte health by regulating immune responses. Sunitinib, an RTK inhibitor, influences angiogenesis processes linked to maintaining the glomerular filtration barrier.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
mTOR inhibitor affecting the PI3K/Akt/mTOR pathway. Suppresses podocyte injury by inhibiting mTORC1 and mTORC2, influencing cellular processes vital for podocyte function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src kinase inhibitor impacting actin cytoskeleton dynamics. Podocyte foot processes are stabilized as Src inhibition affects signaling cascades related to actin remodeling. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMPK activator influencing energy homeostasis. By promoting AMPK activation, it indirectly modulates Podocin through downstream effects on cellular metabolism and stress response. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
GSK-3β inhibitor affecting Wnt signaling. Wnt pathways play a role in podocyte structure maintenance, and GSK-3β inhibition can impact these pathways, influencing Podocin indirectly. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
JAK/STAT pathway inhibitor. Modulates cytokine signaling and immune responses, potentially impacting Podocin through regulation of inflammatory processes related to podocyte health. | ||||||
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Gαq/11 inhibitor influencing intracellular calcium signaling. Podocyte function can be affected indirectly as calcium signaling plays a role in various cellular processes, including podocyte health. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor with immunosuppressive properties. Podocyte injury can be mitigated by inhibiting mTOR, influencing pathways crucial for podocyte structure and function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor impacting Akt/mTOR pathway. Regulates key signaling cascades involved in podocyte function, providing indirect modulation of Podocin. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
S1P receptor modulator impacting immune responses. By regulating immune processes, it can indirectly affect podocyte health, as immune mechanisms are involved in podocyte injury. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
RTK inhibitor affecting angiogenesis. Podocyte function can be indirectly influenced as angiogenic processes are involved in maintaining the glomerular filtration barrier. | ||||||