PNLDC1 Activators
The category of PNLDC1 Activators encompasses a diverse array of chemicals targeting different cellular pathways that have the to influence PNLDC1 activity. A common strategy across these chemicals is the modulation of kinase and phosphatase activity, given their role in phosphorylation, a key post-translational modification. For instance, Forskolin and 8-Bromo-cAMP directly target the PKA pathway by manipulating cAMP levels. This serves to modify the activity of downstream effector molecules that play a role in PNLDC1 activation. Similarly, inhibitors of protein phosphatases like Calyculin A and Okadaic Acid aim to increase the phosphorylation state of proteins, thereby influencing PNLDC1.
Other chemicals in this class aim to perturb specific pathways to create a cellular environment favorable for PNLDC1 activation. For instance, Rapamycin inhibits mTOR, a central regulator of cell growth and metabolism, thereby activating autophagy-related pathways that can lead to PNLDC1 activation. Anisomycin, on the other hand, modulate the JNK pathway, thereby modifying the cellular phosphorylation landscape in a manner that indirectly activates PNLDC1. Each chemical offers a unique avenue for influencing PNLDC1, either through direct phosphorylation or through an induced shift in cellular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can induce the PKA pathway, leading to activation of PNLDC1. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that activates PKA. PKA can phosphorylate factors that elevate PNLDC1 transcription. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits cAMP and cGMP phosphodiesterases, sustaining PKA activity which may lead to PNLDC1 activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates PKC, potentially influencing downstream pathways that lead to PNLDC1 activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation states that can activate PNLDC1. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Inhibits PP1 and PP2A, maintaining a phosphorylation state conducive for PNLDC1 activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, leading to activation of autophagy pathways, which can in turn activate PNLDC1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Activates SIRT1, which deacetylates proteins involved in autophagy, leading to a state that can activate PNLDC1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Activates the JNK pathway, which can then phosphorylate factors involved in PNLDC1 activation. | ||||||