PMCA3 Inhibitors
These inhibitors encompass a range of chemical classes, including SERCA pump inhibitors, calcium channel blockers, calmodulin antagonists, calcium chelators, and modulators of calcium release from intracellular stores. Thapsigargin, a SERCA pump inhibitor, disrupts calcium storage in the endoplasmic reticulum, leading to altered calcium signaling and potentially affecting PMCA3 activity indirectly. 2-APB and TMB-8 modulate various aspects of calcium signaling, including IP3 receptors and intracellular calcium levels, which can influence PMCA3's role in maintaining calcium homeostasis.
Calcium channel blockers such as Verapamil, Nifedipine, Nimodipine, and Amlodipine are well-known for their ability to modulate calcium influx across cell membranes. By altering calcium entry, these agents indirectly affect the calcium extrusion role of PMCA3. Calmidazolium chloride is a calmodulin antagonist; since PMCA3 activity is regulated by calmodulin, its inhibition can indirectly impact PMCA3 function. Similarly, BAPTA-AM, a calcium chelator, by modulating intracellular calcium levels, can influence the activity of PMCA3. Ryanodine and caffeine affect calcium release from intracellular stores, altering calcium dynamics within the cell and potentially impacting PMCA3's function in calcium extrusion. SKF-96365, as an inhibitor of store-operated calcium entry, also plays a role in modulating intracellular calcium levels, indirectly affecting PMCA3.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
A SERCA pump inhibitor that indirectly affects PMCA3 by disrupting calcium homeostasis in the endoplasmic reticulum, leading to altered calcium signaling. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Modulates IP3 receptors and store-operated calcium entry, potentially affecting calcium signaling pathways related to PMCA3 activity. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $156.00 $612.00 | 27 | |
A calmodulin antagonist, potentially influencing PMCA3 function indirectly by affecting calmodulin-dependent processes, including calcium signaling. | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
An intracellular calcium antagonist, which may indirectly influence PMCA3 activity by altering intracellular calcium levels and signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
A calcium channel blocker that can indirectly affect PMCA3 function by modulating calcium influx and intracellular calcium levels. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Another calcium channel blocker, potentially impacting PMCA3 activity indirectly through altered calcium homeostasis. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A calcium chelator that can indirectly affect PMCA3 by modulating intracellular calcium levels. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Modulates ryanodine receptors on the sarcoplasmic and endoplasmic reticulum, potentially affecting calcium release and thereby influencing PMCA3 activity indirectly. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
A calcium channel blocker with specificity for cerebral arteries, potentially affecting PMCA3 indirectly by altering calcium dynamics. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Affects calcium release from the endoplasmic reticulum, potentially altering intracellular calcium levels and indirectly influencing PMCA3 activity. | ||||||