Molecular structure of Ryanodine, CAS Number: 15662-33-6
Ryanodine (CAS 15662-33-6)
See product citations (19)
Alternate Names:
3-(1H-pyrrole-2-carboxylate); Ryanadol
Application:
Ryanodine is a potent modulator of Ryanodine receptor activity
CAS Number:
15662-33-6
Purity:
≥98%
Molecular Weight:
493.55
Molecular Formula:
C25H35NO9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ryanodine is a complex alkaloid natural product and prototypic binder of the Ryanodine Ca2+ channel receptors. Ryanodine receptors regulate intracellular movement of Ca2+, and the storage and release of Ca2+ from the sarcoplasmic reticulum by these receptors has an important role in muscular excitation and contraction. Endogenous regulators of Ca2+ release at the Ryanodine receptors require the presence of Ca2+ for activation of the channels, in an event known as Ca2+-induced Ca2+ release. Ryanodine shows very strong and functionally variable binding on these receptors, with a profoundly deleterious effect on the natural flow of Ca2+ through the channels. Micromolar concentratrions of Ryanodine have been shown to shut down the channels completely, blocking any flux of ions. At lower nanomolar concentrations, Ryanodine locks the channels in a partially open state, leading to depletion of the Ca2+ gradient essential for normal regulation. The toxic effects of Ryanodine are produced by destroying the natural control of Ca2+ release from these receptors. Though originally identified through its toxicity to organisms, Ryanodine has proven an invaluable tool in elucidation of Ca2+ release and its relationship to excitation and contraction of cells.
Ryanodine (CAS 15662-33-6) References
- Potential for pharmacology of ryanodine receptor/calcium release channels. | Xu, L., et al. 1998. Ann N Y Acad Sci. 853: 130-48. PMID: 10603942
- Mechanism of calmodulin inhibition of cardiac sarcoplasmic reticulum Ca2+ release channel (ryanodine receptor). | Xu, L. and Meissner, G. 2004. Biophys J. 86: 797-804. PMID: 14747315
- The brain ryanodine receptor: a caffeine-sensitive calcium release channel. | McPherson, PS., et al. 1991. Neuron. 7: 17-25. PMID: 1648939
- Plant insecticides; ryanodine, a new alkaloid from Ryania speciosa Vahl. | ROGERS, EF. and KONIUSZY, FR. 1948. J Am Chem Soc. 70: 3086-8. PMID: 18882544
- Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat. | Ferrari, LF., et al. 2016. Sci Rep. 6: 31221. PMID: 27499186
- Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming. | Khomula, EV., et al. 2017. J Neurosci. 37: 2032-2044. PMID: 28115480
- Basal ryanodine receptor activity suppresses autophagic flux. | Vervliet, T., et al. 2017. Biochem Pharmacol. 132: 133-142. PMID: 28322744
- A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity. | Murayama, T., et al. 2018. Commun Biol. 1: 98. PMID: 30271978
- Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction. | Arias-Cavieres, A., et al. 2018. Front Cell Neurosci. 12: 403. PMID: 30459562
- Calcium-release channels: structure and function of IP3 receptors and ryanodine receptors. | Woll, KA. and Van Petegem, F. 2022. Physiol Rev. 102: 209-268. PMID: 34280054
- Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome. | Hirose, S., et al. 2022. Europace. 24: 497-510. PMID: 34661651
- Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. | Fabiato, A. 1983. Am J Physiol. 245: C1-14. PMID: 6346892
- Distinct modes of inhibition by ruthenium red and ryanodine of calcium-induced calcium release in avian atrium. | Vites, AM. and Pappano, AJ. 1994. J Pharmacol Exp Ther. 268: 1476-84. PMID: 7511166
- The ryanodine receptor/Ca2+ release channel. | McPherson, PS. and Campbell, KP. 1993. J Biol Chem. 268: 13765-8. PMID: 8390976
- The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states. | Zucchi, R. and Ronca-Testoni, S. 1997. Pharmacol Rev. 49: 1-51. PMID: 9085308
Inhibitor of:
2610021K21Rik, 4930408G06Rik, 4930511M11Rik, 4931407G18Rik, 5730419I09Rik, APBA2BP, ATP11A, ATP13A5, BC024139, C11orf20, C17orf57, C3orf25, CAB39L, CaBP8, CALHM2, Calmegin, CALR3, CaMKIγ, Centrin, Centrin-3, Complexin-4, DANGER, DJBP, DOC2A, E6BP, EG666504, Enkurin, FAM26A, Gm5849, Homer-1, HRC, Intra-acrosomal protein, IP3KC, ITPRIPL1, ITPRIPL2, Junctional SR Marker, Junctophilin-2, Junctophilin-4, MCTP1, MCTP2, Mg29, Mitsugumin23, Nir1, nucleobindin, Olfr347, Olfr716, Olfr9, Olfr976, Olfr982, Olfr983, Otoconin 90, parvalbumin α, phospholamban, piccolo, PMCA3, Recoverin, RPUSD1, RyR, RyR-1, RyR-2, RyR-3, S-100P, S-100Z, SERCA1, Shank 2, SPCA1, STAC3, Synaptotagmin XVII, TMCO1, TMCO7, TMEM63A, TMEM66, TMEM80, TMTC3, Troponin C, Troponin I-SS, Troponin T, Troponin T-FS, Troponin T-SS, Tuftelin, VCAC3, VILIP-2, Vmn1r31, and Wolframin.Activator of:
4931407G18Rik, 5730508B09Rik, 5830403L16Rik, 5830411N06Rik, ACYP1, AHCYL1, ALG2, AMIGO3, ATP13A2, ATP8B4, BC060267, BUP-1, C14orf143, C17orf57, C2CD4D, CaBP2, CaBP4, CaBP5, CaBP8, CALHM1, CALM, CALML5, calmodulin, Calretinin, calsequestrin 1, calsequestrin 2, calsyntenin-3, Calumenin, CaM II, CaM IV, CaMKIβ, CaMKIδ, CaMKIIα, CaMKIIδ, CANT1, CAPS-1, CAPSL, CaT1, CatSperδ, CBARA1, CCDC109B, CHERP, CHP2, CIB2, CLRN2, copine 7, copine 9, CRAMP1L, CRHSP-24, cryptdin 6, CT120, CTTNBP2, DAP-4, DREAM, EF-CAB2, EF-CAB8, EF-HB, ELKS, Fam148b, GAAP, GKAP, Grancalcin, IPMK, IQCC, IQCJ, Jaw1, Junctophilin-1, Junctophilin-3, KChIP4, KCTD7, KIAA0494, KIAA1683, LGICZ1, LHFPL2, Limkain b1, LOC221710, LOC285423, LOC85449, MBLAC1, MLEC, MS4A4C, Munc13-1, Munc13-3, MYBPC1, NCS-1, Neurensin-2, neurocalcin δ, Obscurin, Olr24, Olr245, Olr251, Olr255, Olr263, Orai3, Ost1, Otoferlin, parvalbumin β, PEF, plexin-D1, PMCA4b, PMR1, PP2B-Aβ, PP2B-Aγ, PSD, RasGRP4, reticulocalbin-3, RIM-BP3, Rim3, RNF170, S-100A3, S-100A5, SCaMC-1, SERCA3, SLITRK1, Smooth muscle cells, sorcin, SPACA4, SPCA2, Stim2, Synaptotagmin II, Synaptotagmin III, Synaptotagmin VI, Synaptotagmin VII, Synaptotagmin XI, Synaptotagmin XII, Synaptotagmin XIII, Synaptotagmin XV, Synaptotagmin XVI, Synaptotagmin XVII, TFIIIC110, TMEM155, TMEM167, TMEM16J, TMEM38A, TMEM38B, TMEM63C, TorsinB, TPCN1, TPCN2, Triadin, Troponin I-FS, TRPC4AP, TTYH3, Unc79, UNC93A, USH3AL1, v-SNARE Vti1a, Vmn1r104, Vmn2r21, WDR43, WFDC10, WFDC1A, WFDC6A, WINS2, X123, Xlr3b, Xlr4a, Xlr5a, Xlr5c, Xmr, and zinedin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ryanodine, 1 mg | sc-201523 | 1 mg | $223.00 | |||
Ryanodine, 5 mg | sc-201523A | 5 mg | $799.00 |