PM20D1 Inhibitors
Chemical inhibitors of peptidase M20 domain-containing 1 (PM20D1) can interact with the enzyme in various ways to affect its activity. Palmitic Acid, a saturated long-chain fatty acid, can bind to the active site of PM20D1, which is responsible for the hydrolysis of fatty acid amides. By occupying this site, Palmitic Acid competitively inhibits the enzyme, preventing it from catalyzing its normal reaction. Similarly, Stearic Acid and Myristic Acid, both also long-chain fatty acids, can inhibit PM20D1 by competitive inhibition at the active site, effectively reducing the enzyme's ability to interact with its natural substrates. This inhibition mechanism is shared by other fatty acids such as Arachidonic Acid, Palmitoleic Acid, and Lauric Acid, which can bind to the same active site as the natural substrates, thereby preventing the enzyme from performing its function.
Other fatty acids, such as Oleic Acid and Alpha-Linolenic Acid, can affect PM20D1 by integrating into cellular membranes and potentially changing the membrane fluidity or lipid composition, which can alter the accessibility or conformation of PM20D1, thereby modulating its activity. Linoleic Acid, on the other hand, can act as a substrate mimic, competing with PM20D1's natural substrates due to their structural similarity, leading to competitive inhibition. Furthermore, long-chain polyunsaturated fatty acids like Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) can inhibit PM20D1 by a similar mechanism, where their presence can interfere with the enzyme's normal function by competing with natural substrates for binding to the active site. Additionally, Erucic Acid, with its long-chain structure, can also serve as a competitive inhibitor to PM20D1, engaging the enzyme's active site and reducing its enzymatic activity. Each of these fatty acids can influence the activity of PM20D1, despite differing in their specific interaction mechanisms and the nature of their inhibitory effects.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
Palmitic Acid can inhibit PM20D1 by competitively binding to the active site where the enzyme typically catalyzes the hydrolysis of fatty acid amides. Since PM20D1 functions as a peptidase involved in fat metabolism, the presence of excess palmitic acid could directly inhibit its enzymatic activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid may inhibit PM20D1 by integrating into cellular membranes and affecting membrane fluidity, thus potentially altering the accessibility of PM20D1 to its substrates. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
Linoleic Acid can inhibit PM20D1 by serving as a substrate mimic, inhibiting the enzyme's activity through competition. PM20D1, which is involved in the metabolism of N-acyl amino acids, could be competitively inhibited by linoleic acid due to structural similarity to natural substrates. | ||||||
α-Linolenic Acid | 463-40-1 | sc-205545 sc-205545A | 50 mg 250 mg | $37.00 $113.00 | 2 | |
Alpha-Linolenic Acid could inhibit PM20D1 activity by altering the lipid composition of membranes where PM20D1 is active, potentially inhibiting the protein's capacity to interact with its substrates. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
Eicosapentaenoic Acid (EPA) may inhibit PM20D1 by competing with its natural substrates, thereby inhibiting the enzyme's activity in a similar manner to other long-chain fatty acids. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
Docosahexaenoic Acid (DHA) can inhibit PM20D1 by being a fatty acid that could potentially interfere with the enzyme's normal activity through competitive inhibition or by altering membrane characteristics where PM20D1 is active. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic Acid can act as a competitive inhibitor of PM20D1 by mimicking its natural substrates, thus potentially blocking the enzyme's function. | ||||||
Myristic Acid | 544-63-8 | sc-205393 sc-205393A sc-205393B | 1 g 5 g 50 g | $30.00 $75.00 $300.00 | 1 | |
Myristic Acid could inhibit PM20D1 by competing for the active site of the enzyme, which may lead to a decrease in PM20D1 activity since it is structurally similar to natural substrates of PM20D1. | ||||||
Palmitoleic acid | 373-49-9 | sc-205424 sc-205424A sc-205424B sc-205424C sc-205424D | 100 mg 500 mg 1 g 5 g 10 g | $32.00 $132.00 $233.00 $1019.00 $1870.00 | 4 | |
Palmitoleic Acid may inhibit PM20D1 by binding to the active site and competing with the natural substrates of the enzyme, thus potentially inhibiting its activity. | ||||||
Stearic Acid | 57-11-4 | sc-203408 sc-203408A sc-203408B | 100 g 1 kg 5 kg | $25.00 $31.00 $115.00 | 1 | |
Stearic Acid can inhibit PM20D1 by competing with the enzyme's natural substrates, as its long-chain fatty acid structure is similar to those substrates, potentially leading to inhibition of PM20D1's enzymatic function. | ||||||