Plk Activators
Common Plk Activators include, but are not limited to 5-Azacytidine CAS 320-67-2, Trichostatin A CAS 58880-19-6, Etoposide (VP-16) CAS 33419-42-0, Retinoic Acid, all trans CAS 302-79-4 and Taxol CAS 33069-62-4.
Plk Activators constitute a distinctive subset of chemical compounds known for their capacity to modulate the activity of polo-like kinases (Plks). This chemical class functions by interacting with and enhancing the signaling pathways associated with Plks, a family of serine/threonine protein kinases crucial for the regulation of various cell cycle processes. Plks are recognized for their roles in cell division, DNA damage response, and centrosome maturation, making them essential components of cellular replication and maintenance.
Plk Activators exert their influence through specific molecular interactions that may amplify the downstream effects of Plk-mediated signaling, contributing to the fine-tuning of cell cycle progression, chromosome segregation, and cellular responses to DNA damage. The intricate mechanisms through which Plk Activators impact Plk-related pathways remain an area of ongoing scientific exploration, providing insights into the complex coordination of cell cycle events and genomic stability. The specific ways in which this chemical class engages with Plks underline its significance in unraveling the complexities of cell division regulation and enhancing our understanding across various scientific domains.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a demethylating agent that can induce Plk1 expression by inhibiting DNA methylation. Increased Plk1 expression can affect cell cycle progression and mitotic activity. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is a histone deacetylase inhibitor that can lead to increased Plk1 expression. It affects epigenetic modifications on histones, ultimately influencing cell cycle control | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, can induce Plk1 expression. Its mechanism of action involves DNA damage and cell cycle arrest | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, can induce Plk1 expression. It has been explored for its potential to regulate cell differentiation and proliferation | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel is a microtubule-stabilizing compound that can lead to Plk1 induction. Its effects on microtubules influence mitotic spindle formation and Plk1 activation | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor that may induce Plk1 expression, potentially impacting cell cycle progression and mitotic functions | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a widely used compound that can induce Plk1 expression. It triggers DNA damage responses and influences cell cycle checkpoints | ||||||
Aurora Kinase/Cdk Inhibitor | 443797-96-4 | sc-203829 | 5 mg | $440.00 | ||
Compounds targeting Aurora kinases, such as Aurora A, can lead to compensatory Plk1 induction. These inhibitors affect mitotic progression and centrosome function | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, a form of estrogen, can induce Plk1 expression. It plays a role in various cellular processes, including cell cycle progression and gene regulation | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is a ribonucleotide reductase inhibitor that can induce Plk1 expression. It affects DNA synthesis and replication, influencing cell cycle checkpoints | ||||||