Plexin Inhibitors
Plexin signaling plays a fundamental role in various biological processes, including neuronal development, immune responses, and the regulation of cell migration. Plexins act as receptors for semaphorins, a class of secreted or membrane-bound proteins, which are involved in guiding neuronal axons and vascular patterning. Upon binding with semaphorins, Plexin receptors undergo a conformational change that triggers intracellular signaling cascades. These cascades often involve the regulation of the cytoskeleton, impacting cell shape and movement. Moreover, Plexin signaling is crucial in angiogenesis and immune cell regulation, influencing tissue development and repair processes.
Targeting Plexin pathways for disruption or inhibition is of significant interest. Inhibiting Plexin-semaphorin interactions can modulate the signaling pathways, altering pathological processes like tumor growth or abnormal neuronal development. Small molecule inhibitors, antibodies, or peptides that either mimic or block the action of semaphorins can be used to disrupt Plexin signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Inhibits the Hedgehog signaling pathway, which is known to interact with Plexin mediated pathways, thereby potentially altering the functional outcomes of Plexin-B2 activity. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
A selective FGFR tyrosine kinase inhibitor, can affect cellular processes modulated by Plexin as the FGFR pathway can crosstalk with Plexin signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which can interact with Plexin signaling pathways, thereby influencing cellular responses to Plexin-B2. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibits p38 MAPK, potentially affecting Plexin mediated cellular processes as p38 MAPK is known to be involved in Plexin signal transduction. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Disrupts Rac1 activation, potentially interfering with Plexin mediated cytoskeletal reorganization. | ||||||
IQ-1 | 331001-62-8 | sc-202665 | 10 mg | $180.00 | 2 | |
A CDC42 inhibitor, possibly altering Plexin's role in actin cytoskeleton reorganization and cell migration, as CDC42 is a critical mediator in these processes. | ||||||
2-undecyl-thiazolidine-4-carboxylic acid | 298186-80-8 | sc-220768 sc-220768A | 5 mg 10 mg | $88.00 $166.00 | ||
As a 5-lipoxygenase inhibitor, it may affect arachidonic acid metabolism, which can influence Plexins role in inflammation and related signaling cascades. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A Rho-associated protein kinase (ROCK) inhibitor that can modulate Plexin signaling pathways involved in cellular motility and morphology. | ||||||