plexin-C1 Activators
Plexin-C1 Activators are a class of compounds that enhance the function of the plexin-C1 protein through diverse mechanisms, primarily via activation of specific signaling pathways that lead to increased ubiquitination processes. These compounds range from small organic molecules such as anisomycin, etoposide, and sorbitol, to biological molecules like epidermal growth factor (EGF), insulin, and tumor necrosis factor alpha (TNFα). Anisomycin, sodium arsenite, thapsigargin, and tunicamycin are potent activators of the JNK pathway, a key regulator of cell stress responses. Activating the JNK pathway can lead to phosphorylation of substrates involved in ubiquitination, thereby enhancing the function of plexin-C1 in signal transduction.
Meanwhile, Etoposide, a DNA damage response modulator, can activate the ATM/ATR pathway, leading to enhanced ubiquitination processes and increased plexin-C1 functionality. Paclitaxel, sorbitol, and hydrogen peroxide (H2O2) act by stabilizing microtubules and inducing osmotic and oxidative stress respectively, leading to activation of the MAPK pathway, a crucial route to ubiquitination. Compounds such as EGF, insulin, and TNFα trigger their respective receptor pathways – the EGFR, insulin receptor, and NF-κB pathways – which are interconnected with the MAPK pathway. This interconnection provides an alternative route to enhancing ubiquitination processes, and subsequently, plexin-C1 function. Lastly, U0126, a selective inhibitor of MEK1/2, indirectly activates upstream components of the MAPK pathway, leading to increased ubiquitination and enhanced plexin-C1 functionality.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of the JNK pathway, which plays a role in cell stress response. Upon its activation, JNK can phosphorylate substrates that are involved in ubiquitination processes, thereby enhancing the function of plexin-C1 in signal transduction. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide is known to activate the ATM/ATR pathway which is involved in response to DNA damage. The activated ATM/ATR pathway can lead to the activation of ubiquitination processes, enhancing the function of plexin-C1 in signal transduction. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol (Paclitaxel) stabilizes microtubules, leading to activation of the MAPK pathway. Activation of MAPK can lead to the activation of ubiquitination processes, thereby enhancing the function of plexin-C1 in signal transduction. | ||||||
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Sorbitol is a well-known osmotic stress inducer that activates the p38 MAPK pathway. Activated p38 MAPK can enhance ubiquitination processes, thereby enhancing the function of plexin-C1. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite can induce oxidative stress, leading to the activation of the JNK pathway. The activation of JNK results in the activation of ubiquitination processes, thereby enhancing the function of plexin-C1. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
H2O2 induces oxidative stress and activates the p38 MAPK and JNK pathways. The activation of these pathways leads to the activation of ubiquitination processes, enhancing the function of plexin-C1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress and activates the JNK pathway. The activated JNK enhances ubiquitination processes, thereby enhancing the function of plexin-C1. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin induces endoplasmic reticulum stress and activates the JNK pathway. The activated JNK enhances ubiquitination processes, thereby enhancing the function of plexin-C1. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor pathway, which is linked to the MAPK pathway. Activation of MAPK can lead to the activation of ubiquitination processes, thereby enhancing the function of plexin-C1. | ||||||