plakophilin 4 Inhibitors
Plakophilin 4 inhibitors belong to a specific chemical class designed to target and regulate the activity of plakophilin 4, a protein that plays a crucial role in cell-cell adhesion and tissue integrity. Plakophilin 4 is a member of the plakophilin family, which are desmosomal proteins found primarily in tissues subjected to mechanical stress, such as the heart, skin, and epithelial linings. These proteins are essential components of desmosomes, cell junctions that provide strong adhesion between neighboring cells and contribute to the maintenance of tissue integrity. Plakophilin 4, in particular, is known for its role in linking the desmosomal cadherins to the intermediate filament cytoskeleton, reinforcing cell-cell adhesion and contributing to tissue stability. Plakophilin 4 inhibitors are designed to interfere with its molecular interactions or functions, offering a means to investigate the precise role of this protein in cellular adhesion and tissue homeostasis.
The development and study of plakophilin 4 inhibitors are of great significance in the fields of cell biology and molecular biology, as they enable researchers to dissect the mechanisms underpinning desmosomal function and cell-cell adhesion. By selectively inhibiting plakophilin 4, scientists can investigate its specific contributions to the structural integrity of tissues and its involvement in various physiological processes. Moreover, plakophilin 4 inhibitors may find applications in basic research settings, where the controlled modulation of desmosomal components can be used to uncover the broader implications of cell adhesion and cytoskeletal interactions in cellular and tissue physiology. Overall, these inhibitors serve as valuable tools for advancing our understanding of plakophilin 4's role in cellular adhesion and tissue biology.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor affecting cell adhesion and might influence Plakophilin 4 indirectly. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II and affects cell shape, which might indirectly impact Plakophilin 4. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
CDC42 inhibitor affecting cell mobility and might influence Plakophilin 4 indirectly. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin filaments and cell adhesion, could have off-target effects on Plakophilin 4. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments; might indirectly influence Plakophilin 4 expression. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Affects various pathways, including those related to cell adhesion and might impact Plakophilin 4. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
N-WASP inhibitor affecting cell mobility, might have off-target effects on Plakophilin 4. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin proteins, affecting actin dynamics, which might indirectly influence Plakophilin 4. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Arp2/3 complex inhibitor; affects cell structure and might impact Plakophilin 4. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
PAK1 inhibitor affecting cell mobility, which might indirectly influence Plakophilin 4. | ||||||