PKNβ Activators
PKNβ (Protein Kinase N Beta) is a member of the protein kinase C (PKC) superfamily and is encoded by the PKN2 gene in humans. This kinase is a serine/threonine kinase, meaning it phosphorylates specific serine or threonine amino acids in protein substrates. PKNβ is involved in a variety of cellular processes, including regulation of cell cycle, cytoskeletal organization, and cell motility.One of the defining features of PKNβ is its sensitivity to lipid second messengers, particularly those generated through phospholipase C-mediated hydrolysis of phosphatidylinositol 4,5-bisphosphate. This lipid sensitivity places PKNβ in a unique position to respond to various extracellular signals, making it an important mediator in signal transduction pathways.
PKNβ has also been implicated in the regulation of several transcription factors and genes, thereby influencing gene expression. Its role in the cytoskeleton organization makes it vital for cell shape and movement, processes essential in development and tissue repair. Abnormalities in PKNβ function have been linked to various pathological conditions, including cancer. Its involvement in cell proliferation and survival pathways suggests a role in oncogenesis, and alterations in PKNβ expression or activity have been observed in certain types of cancer.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent, non-selective kinase inhibitor, could indirectly affect PKNβ through broad kinase inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Inhibits Protein Kinase C (PKC), potentially impacting signaling pathways relevant to PKNβ. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A PKC inhibitor, may influence signaling pathways that intersect with PKNβ's role. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, potentially affecting pathways that intersect with PKNβ activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, a key regulator of cell growth and proliferation, potentially influencing PKNβ activity. | ||||||
Rottlerin | 82-08-6 | sc-3550 sc-3550B sc-3550A sc-3550C sc-3550D sc-3550E | 10 mg 25 mg 50 mg 1 g 5 g 20 g | $82.00 $163.00 $296.00 $2050.00 $5110.00 $16330.00 | 51 | |
Traditionally considered a PKC delta inhibitor, may affect related pathways involving PKNβ. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
A MEK inhibitor, could impact signaling pathways involving PKNβ. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, could impact signaling pathways relevant to PKNβ. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubules, potentially influencing PKNβ-related cellular processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Stabilizes microtubules, potentially affecting PKNβ activity in cytoskeletal dynamics. | ||||||