PIPK II γ Inhibitors
Phosphoinositide kinases (PIPKs) are a family of lipid kinases responsible for the phosphorylation of phosphoinositides, a group of specialized phospholipids that play crucial roles in cellular signaling, membrane trafficking, and cytoskeletal dynamics. Among the different classes of PIPKs, phosphatidylinositol 4-phosphate 5-kinase type II gamma (PIPK II γ) stands out due to its unique substrate specificity and cellular distribution. These kinases act on specific phosphoinositide substrates to produce phosphoinositide products, which in turn serve as secondary messengers to relay cellular signals or act as docking sites for specific protein complexes, modulating various cellular functions.
Inhibitors targeting PIPK II γ modulate the activity of this kinase, impacting the balance of phosphoinositides within the cell. By doing so, they can influence a variety of cellular processes orchestrated by these lipids. Given the central role of phosphoinositides in numerous cellular activities, including signal transduction, vesicle trafficking, and cytoskeletal regulation, modulating the activity of PIPK II γ can profoundly influence cellular behavior. The specificity of these inhibitors towards PIPK II γ and their ability to alter its kinase activity can provide insight into the complex web of phosphoinositide-regulated pathways and processes. Overall, PIPK II γ inhibitors represent valuable tools in the study of cellular signaling, offering a means to dissect the intricate roles of phosphoinositides in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PI 3-Kγ Inhibitor | 648450-29-7 | sc-203191 | 5 mg | $76.00 | ||
AS-605240 selectively inhibits PI3Kγ with IC50 value in the nanomolar range. It suppresses immune cell migration and inflammation by blocking the downstream effects of PI3Kγ activation, including AKT phosphorylation and Rac activation. | ||||||
TG100-115 | 677297-51-7 | sc-364634 sc-364634A | 5 mg 100 mg | $250.00 $1873.00 | 1 | |
TG100-115 inhibits PI3Kγ and PI3Kδ. It disrupts the PI3K signaling pathway, subsequently reducing downstream mediators like AKT phosphorylation. This can lead to decreased cell survival and proliferation in various cell types. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is known to inhibit PI3Kγ with significant potency. By doing so, it reduces the downstream PI3K signaling, including the activation of AKT, which is vital for various cellular functions, including survival and migration. | ||||||
TGR-1202 | 1532533-67-7 | sc-507436 | 25 mg | $286.00 | ||
TGR-1202 is a selective PI3Kδ inhibitor but also has effects on PI3Kγ. By inhibiting PI3Kγ and δ, it disrupts downstream cellular signaling pathways, which are essential for cellular proliferation and survival, particularly in lymphocytes. | ||||||
CH5132799 | 1007207-67-1 | sc-364460 sc-364460A | 5 mg 50 mg | $360.00 $1650.00 | ||
CH5132799 is a class I PI3K inhibitor that inhibits all class I PI3K isoforms, including γ. By doing so, it reduces the activation of the PI3K-AKT-mTOR signaling pathway, influencing cell growth, survival, and metabolism in a variety of cell types. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
SAR405 is a potent and selective PI3Kδ inhibitor but has shown activity against PI3Kγ as well. By targeting PI3K isoforms, it influences lymphocyte activation, proliferation, and survival by altering the downstream signaling cascade. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
IC87114 selectively inhibits PI3Kδ but also has some activity against PI3Kγ. By inhibiting these isoforms, it affects downstream cellular signaling processes, especially those related to immune cell function and inflammation. | ||||||