PI 3-kinase p101 Inhibitors
PI 3-kinase p101 inhibitors encompass a group of chemical compounds that are designed to reduce or abolish the activity of the p101 regulatory subunit of class IB phosphoinositide 3-kinases (PI3Ks). The p101 subunit associates with the p110γ catalytic subunit to form a functional enzyme that is involved in the phosphoinositide signaling pathway, which plays a pivotal role in various cellular processes such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking. The mechanism of action of PI 3-kinase p101 inhibitors can be direct, where the compounds bind to the p101 subunit itself, interfering with its ability to associate with the p110γ subunit or altering its conformation in such a way that the PI3K enzyme's activity is reduced. This could prevent the production of the second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3), effectively dampening downstream signaling pathways.
Indirect inhibitors, on the other hand, might act by modulating the expression levels of p101 or by affecting its post-translational modifications, which are crucial for its stability and interaction with p110γ. They could also influence other regulatory proteins or upstream signaling molecules that impact the activity of p101-containing PI3K enzymes. Studying PI 3-kinase p101 inhibitors is important for researchers who are interested in the intricate network of cellular signaling. By employing these inhibitors, scientists can investigate the specific contributions of the p101 regulatory subunit and the class IB PI3Ks to cellular functions and signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY2 94002, a synthetic molecule, could downregulate PI 3-kinase p101 expression by inhibiting the kinase activity of PI3K, resulting in decreased phosphorylation and activation of downstream effectors that may be involved in the transcriptional control of the p101 gene. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin may reduce the expression of PI 3-kinase p101 by irreversibly binding to the active site of PI3K, thereby diminishing the kinase's ability to propagate signals that upregulate p101 transcription within the cell. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, by inhibiting mTOR complex 1 (mTORC1), could decrease the synthesis of PI 3-kinase p101 by attenuating the cap-dependent translation process, which is essential for the production of many regulatory proteins. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
BEZ235, a dual PI3K/mTOR inhibitor, might suppress the expression of PI 3-kinase p101 by concurrently obstructing the PI3K signaling and the protein synthesis machinery regulated by mTOR, thereby hindering the cellular capacity to produce the p101 protein. | ||||||
AZD6482 | 1173900-33-8 | sc-364422 sc-364422A | 5 mg 10 mg | $275.00 $390.00 | 1 | |
AZD6482, by selectively targeting p110β, a catalytic subunit of PI3K, could lead to a reduction in PI 3-kinase p101 expression as a compensatory response to the specific inhibition of this PI3K isoform's activity. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103, a potent inhibitor of several PI3K isoforms, including mTOR, could disrupt multiple signaling cascades, resulting in a comprehensive reduction in the cellular levels of PI 3-kinase p101 due to broad suppression of the pathway. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $189.00 | 4 | |
Cal-101, by preferentially inhibiting p110δ, could lead to decreased expression of PI 3-kinase p101 by specifically hindering the kinase activity of PI3K in lymphocytes, potentially affecting the gene expression profiles within these cells. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $184.00 $195.00 | 2 | |
GDC-0941 may decrease PI 3-kinase p101 expression through its selective inhibition of class I PI3K, reducing the phosphorylation of downstream targets involved in the stability and production of the p101 subunit. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU 0063794, an mTOR inhibitor, could decrease the cellular expression of PI 3-kinase p101 by reducing the activity of mTORC2, which has been shown to control the assembly and stability of certain PI3K complexes. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
ZSTK474 may downregulate the expression of PI 3-kinase p101 through its pan-PI3K inhibitory action, leading to a decrease in the autophosphorylation events that typically promote the transcription and translation of PI3K complex components. | ||||||