PHYHIP Inhibitors
PHYHIP inhibitors encompass a set of chemical compounds designed to target and modulate the activity or expression of the PHYHIP protein. PHYHIP, an acronym for phytanoyl-CoA 2-hydroxylase interacting protein, interacts with PHYH, a pivotal enzyme involved in the breakdown of branched-chain fatty acids in peroxisomes. While PHYH is directly involved in the alpha-oxidation of phytanic acid, the exact function of PHYHIP is not entirely clear. It is postulated that PHYHIP may play roles in stabilizing or assisting the function of PHYH. Given the potential importance of PHYHIP in lipid metabolism, especially in relation to PHYH, the interactions of PHYHIP inhibitors with the protein can have significant cellular consequences.
The mechanisms by which PHYHIP inhibitors operate can vary. Some might have a direct affinity for the PHYHIP protein, binding to specific domains or active sites, thereby altering its conformation and modulating its interaction with PHYH or other cellular components. Others might act at a genetic level, influencing transcriptional or translational processes of the gene encoding PHYHIP. Additionally, there might be inhibitors that impact post-translational modifications of PHYHIP, affecting its stability, localization, or interactions within the cell. As the understanding of the PHYHIP protein and its role in cellular metabolism deepens, the specificity, mechanism of action, and broader cellular impacts of these inhibitors will come into sharper focus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis, which could downregulate the expression of PHYHIP by preventing its transcription. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide blocks protein synthesis by interfering with the translation process, potentially preventing the synthesis of PHYHIP protein. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Mycophenolic acid inhibits inosine monophosphate dehydrogenase, affecting purine synthesis. This might influence RNA synthesis and PHYHIP expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could alter the methylation pattern of the genome, potentially impacting PHYHIP expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor might affect gene expression by modifying chromatin structure, which could influence PHYHIP expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, potentially affecting DNA synthesis and indirectly PHYHIP gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
By inhibiting RNA polymerase II, alpha-amanitin might reduce the transcription of PHYHIP. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a regulator of protein synthesis, potentially impacting PHYHIP protein synthesis. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to Hsp90, potentially affecting the folding or stability of PHYHIP. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin binds to ribosomes, inhibiting protein synthesis, which could prevent the production of PHYHIP protein. | ||||||