Peroxin 12 Activators
Peroxin 12 Activators encompass a diverse range of chemicals that can indirectly influence the activation or upregulation of the ribosomal protein Peroxin 12 (PEX12). These activators primarily function by modulating various cellular pathways intricately linked to peroxisomal biogenesis and function. For instance, Pioglitazone and Rosiglitazone, both PPARγ agonists, stimulate the transcription of genes involved in peroxisomal biogenesis. This promotion of peroxisome formation can increase the demand for essential proteins like PEX12. Similarly, Fenofibrate, a PPARα agonist, enhances peroxisomal fatty acid oxidation, leading to an increased activity that necessitates the upregulation of PEX12, which is crucial for importing proteins into the peroxisome.
Furthermore, chemicals like Wy-14643 and Bezafibrate play pivotal roles in peroxisomal proliferation. As the number of peroxisomes in a cell rises, the cellular demand for PEX12 can also escalate to maintain proper peroxisomal function. Dexamethasone, a glucocorticoid, has been shown to increase the number of peroxisomes in certain cell types, further emphasizing the indirect influence on PEX12 levels. Compounds like Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) modulate peroxisomal lipid metabolism pathways, which can indirectly affect the demand for PEX12.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Activating PPARα with fenofibrate enhances peroxisomal fatty acid oxidation, indirectly necessitating the upregulation of PEX12. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone can stimulate peroxisomal biogenesis, indirectly increasing the need for PEX12 in the protein import machinery of the newly formed peroxisomes. | ||||||
WY 14643 | 50892-23-4 | sc-203314 | 50 mg | $133.00 | 7 | |
This synthetic PPARα agonist can enhance peroxisomal proliferation, indirectly driving the need for more PEX12 in the cell. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate can stimulate the biogenesis of peroxisomes, indirectly influencing the levels and activity of PEX12. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can increase the number of peroxisomes in certain cell types, indirectly increasing the demand for PEX12 to facilitate protein import. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate can induce peroxisomal proliferation, indirectly driving the need for more PEX12 in the cell. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $92.00 $206.00 $1744.00 $7864.00 $16330.00 | 11 | |
DHA can influence peroxisomal metabolism, indirectly affecting the demand for PEX12. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA can modulate peroxisomal pathways, potentially influencing the levels and activity of PEX12. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
While primarily involved in mitochondrial fatty acid transport, L-carnitine can also influence peroxisomal function, indirectly necessitating the upregulation of PEX12. | ||||||