PECAM-1 Activators
PECAM-1 Activators are a fascinating subset of molecules within the field of biochemical research. These compounds belong to the class of proteins and ligands that interact with Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1), a cell surface glycoprotein primarily found on endothelial cells, platelets, and various immune cells. PECAM-1, also known as CD31, plays a crucial role in various cellular processes, particularly in cell adhesion, signaling, and immune response regulation. Activators of PECAM-1 are compounds or agents that modulate the activity of this glycoprotein, which, in turn, can have significant implications for cell-cell interactions and immune system functioning.
PECAM-1 Activators function by binding to PECAM-1 receptors, often triggering intracellular signaling cascades. These interactions can lead to changes in cell adhesion, migration, and signaling pathways. Researchers study these activators to gain insights into the fundamental biological roles of PECAM-1 and its involvement in immune responses and cell adhesion. Understanding the molecular interactions between PECAM-1 and its activators is crucial for unraveling the complexities of cell biology and immunology, paving the way for potential future applications in various research fields.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), leading to the phosphorylation and activation of PECAM-1. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a phosphatase inhibitor that enhances the phosphorylation state of PECAM-1 by preventing its dephosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a phosphatase inhibitor that maintains the phosphorylation of PECAM-1 by inhibiting dephosphorylation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
H2O2 induces oxidative stress, leading to the phosphorylation and activation of PECAM-1. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin, a serine protease, activates PECAM-1 through various signaling pathways, including phosphorylation. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $240.00 $1275.00 | 40 | |
U46619 mimics thromboxane A2, promoting platelet activation and consequently, PECAM-1 activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that raises intracellular calcium levels, leading to PECAM-1 activation. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP activates purinergic receptors on the cell surface, resulting in intracellular calcium influx and PECAM-1 activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, another calcium ionophore, elevates intracellular calcium levels, leading to PECAM-1 activation. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate inhibits protein tyrosine phosphatases, promoting the phosphorylation and activation of PECAM-1. | ||||||