PDDC1 Inhibitors
PDDC1, also known as Polycomb group RING finger protein 5 (PCGF5), is a component of the Polycomb repressive complex 1 (PRC1). PRC1 is a multi-protein complex that plays a pivotal role in the maintenance of gene silencing through histone modification. Specifically, PRC1 has been shown to mono-ubiquitinate histone H2A, leading to the repression of specific genes. PDDC1, as a part of this complex, is believed to contribute to the stability and function of PRC1, ensuring the proper regulation of target genes.
Inhibitors targeting PDDC1 aim to modulate the activity of the PRC1 complex by disrupting the function of PDDC1. By doing so, these inhibitors can change the epigenetic landscape of the cell, leading to the activation or deactivation of specific genes. The design and development of PDDC1 inhibitors are based on the structural and functional understanding of the PRC1 complex and the specific role of PDDC1 within this assembly. The specificity and selectivity of these inhibitors are crucial to ensure that they target PDDC1 without significantly affecting other proteins or pathways in the cell. As our understanding of the molecular mechanisms governing PRC1 and PDDC1 deepens, the design of more potent and selective inhibitors becomes feasible, offering a tool to further study the intricate processes of epigenetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Nitropropionic acid | 504-88-1 | sc-214148 sc-214148A | 1 g 10 g | $80.00 $450.00 | ||
3-Nitropropionic acid is a PDC1 inhibitor that competes with pyruvate for binding to the enzyme's active site. This prevents PDC1 from catalyzing the conversion of pyruvate to acetaldehyde and carbon dioxide. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $74.00 | 1 | |
Fomepizole is a PDC1 inhibitor that acts as a non-competitive inhibitor of the enzyme. This means that it binds to PDC1 at a site other than the active site, which causes the enzyme to change its conformation and become inactive. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a PDC1 inhibitor that acts by inhibiting the Na+/K+ ATPase pump. This prevents the pump from maintaining the electrochemical gradient across the cell membrane, which is required for PDC1 activity. | ||||||
Dichloroacetic acid | 79-43-6 | sc-214877 sc-214877A | 25 g 100 g | $60.00 $125.00 | 5 | |
DCA is a PDC1 inhibitor that is thought to work by activating pyruvate dehydrogenase kinase (PDK), which is an enzyme that inhibits PDC1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a PDC1 inhibitor that is thought to work by multiple mechanisms, including inhibiting the enzyme's activity and disrupting its structure. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a PDC1 inhibitor that is thought to work by multiple mechanisms, including inhibiting the enzyme's activity and disrupting its structure. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin is a PDC1 inhibitor that is thought to work by multiple mechanisms, including inhibiting the enzyme's activity and disrupting its structure. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol is a PDC1 inhibitor that is thought to work by multiple mechanisms, including inhibiting the enzyme's activity and disrupting its structure. | ||||||