PCDHA6 Activators
The class of chemicals known as PCDHA6 Activators includes compounds that interact with cellular signaling pathways and gene expression mechanisms, thereby indirectly influencing the activity or expression of PCDHA6. These activators encompass a variety of mechanisms, such as the modulation of gene transcription via retinoid and vitamin D receptors by retinoic acid and vitamin D3, respectively. They engage with pathways that are known to affect the expression of cadherin family genes, to which PCDHA6 belongs.
Lithium chloride's inhibition of GSK-3, as well as dibutyryl-cAMP's mimicry of cAMP, can activate PKA, resulting in alterations in PCDHA6 activity. Epigenetic modulators like sodium butyrate and trichostatin A also represent a critical class of PCDHA6 activators, as they can lead to an upregulation of gene expression by altering chromatin accessibility. Additionally, small molecule modulators such as genistein and bisphenol A can influence cell signaling by inhibiting specific kinases or binding to receptors, leading to changes in the expression patterns of various genes, including PCDHA6.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that can modulate gene expression. It can influence the expression of cadherins by binding to retinoic acid receptors, which may lead to the upregulation of PCDHA6 expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
A glycogen synthase kinase 3 (GSK-3) inhibitor that can activate the Wnt signaling pathway, which has been shown to regulate cadherin expression and could thereby increase the expression of PCDHA6. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that can activate protein kinase A (PKA) and potentially lead to changes in cellular adhesion and cadherin expression, which might include PCDHA6. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Its active form, calcitriol, acts as a ligand for the vitamin D receptor, which can influence gene expression, possibly including that of PCDHA6. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
An isoflavone that acts as a tyrosine kinase inhibitor; it can modulate signaling pathways that might lead to changes in cadherin expression, potentially affecting PCDHA6. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium ions can modulate NMDA receptor activity, which may influence intracellular signaling pathways related to cadherin function and expression, including PCDHA6. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A histone deacetylase inhibitor that can lead to chromatin remodeling and influence gene expression patterns, potentially upregulating PCDHA6. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
An endocrine disruptor that can bind to estrogen receptors and may have downstream effects on gene expression, possibly influencing PCDHA6 levels. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Involved in methylation processes, which can affect gene expression, potentially including that of PCDHA6. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylase that can change the expression levels of many genes, including potentially PCDHA6, by altering chromatin structure. | ||||||