PCDHA6 Antibody (S-13): sc-81799

PCDHA6 Antibody (S-13) is a mouse monoclonal IgG2a kappa light chain antibody that detects PCDHA6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHA6 antibody (S-13) is available as a non-conjugated format. PCDHA6, a member of the cadherin-related neuronal receptor family, plays a crucial role in the development and function of the nervous system by mediating cell-cell adhesion, which is essential for maintaining the structural integrity of tissues and facilitating neuronal connectivity. PCDHA6, along with its relatives in the cadherin superfamily, is characterized by six cadherin repeats in the extracellular domain that enable calcium-dependent adhesion, while its unique cytoplasmic domain distinguishes PCDHA6 from other cadherins. PCDHA6 interaction with Fyn, a protein tyrosine kinase, is particularly significant as PCDHA6 is involved in the signaling pathways that shape brain networks and influence behavior. Understanding PCDHA6 function and interactions is vital for elucidating the mechanisms underlying neural development and the potential implications in neurodevelopmental disorders.

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PCDHA6 Antibody (S-13) References:

1. Desmosomal cadherins: another growing multigene family of adhesion molecules.  |  Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
2. Cadherins and catenins: interactions and functions in embryonic development.  |  Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
3. Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.  |  Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
4. Morphogenetic roles of classic cadherins.  |  Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335
5. Molecular cloning of Fyn-associated molecules in the mouse central nervous system.  |  Kai, N., et al. 1997. J Neurosci Res. 48: 407-24. PMID: 9185665
6. Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.  |  Kohmura, N., et al. 1998. Neuron. 20: 1137-51. PMID: 9655502
7. Fyn, a Src family tyrosine kinase.  |  Resh, MD. 1998. Int J Biochem Cell Biol. 30: 1159-62. PMID: 9839441

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCDHA6 Antibody (S-13) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PCDHA6 Antibody (S-13) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCDHA6 Antibody (S-13) Specifications

Alternate Product Name: PCDHA6

Product Clone Name: S-13

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 295-371

Epitope Target: PCDHA6

Epitope Species: human

Product Reactivity/Detection: PCDHA6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PCDHA6 Antibody (S-13): N/A