Pax-7 Activators
Common Pax-7 Activators include, but are not limited to Genistein CAS 446-72-0, Salubrinal CAS 405060-95-9, Nicotinamide CAS 98-92-0, Retinoic Acid, all trans CAS 302-79-4 and Forskolin CAS 66575-29-9.
Pax-7 Activators belong to a category of molecules or compounds that play a crucial role in modulating the activity of the Pax-7 gene, particularly its transcription factor product. The Pax-7 gene is a member of the paired box (Pax) family of transcription factors, which are vital in various aspects of embryonic development, tissue regeneration, and stem cell regulation. Pax-7, in particular, holds significant importance as it is a key regulator in the context of skeletal muscle development and satellite cell maintenance, which is fundamental for muscle growth and repair. Activators within this class can be defined as substances or mechanisms that positively influence the expression or activity of Pax-7, ultimately leading to an increase in the transcription of target genes involved in muscle development and regeneration.
During embryonic development, Pax-7 assumes a critical role in the formation of skeletal muscle. It exerts control over the proliferation and differentiation of myogenic precursor cells, a group of cells essential for postnatal muscle growth and repair. Pax-7 is especially significant in maintaining satellite cells, a specific type of precursor cell, in a quiescent state until they are called upon for muscle regeneration in response to injury or physical exertion. When activated, Pax-7 fosters the differentiation of these satellite cells into mature muscle fibers. A comprehensive understanding of Pax-7 Activators is of immense importance in the fields of regenerative medicine and muscle biology. Such knowledge can lead to groundbreaking advances in muscle repair strategies. It opens up avenues for unraveling the intricate regulatory mechanisms governing muscle development and regeneration, offering insights into how we might harness the body's innate regenerative systems to enhance muscle healing processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
HDAC inhibitor that opens chromatin structure near the Pax-7 start site for improved transcription factor binding. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
eIF2α phosphatase inhibitor preventing inhibitory phosphorylation of ATF4, allowing its interaction with cAMP response elements in the Pax-7 locus. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Inhibits SIRT1 to maintain acetylation of histones near the Pax-7 promoter and enhance accessibility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate the expression of various genes, potentially including PAX7, through its action on retinoic acid receptors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, raising cAMP levels, which might influence PAX7 expression through cAMP-responsive elements. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This glucocorticoid can influence PAX7 expression, possibly as part of its broader effects on muscle metabolism and inflammation. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
PPARγ agonist which activates PPRE elements in an intronic enhancer region of Pax-7. | ||||||