patched Inhibitors
Common patched Inhibitors include, but are not limited to Vismodegib CAS 879085-55-9, Erismodegib CAS 956697-53-3, Cyclopamine CAS 4449-51-8, HPI-4 CAS 302803-72-1 and Itraconazole CAS 84625-61-6.
Patched inhibitors belong to a specific chemical class of compounds that are designed to target and inhibit the activity of the Patched (PTCH) protein. Patched is a crucial component of the Hedgehog signaling pathway, a signaling cascade that plays a fundamental role in embryonic development, tissue maintenance, and cell differentiation in various organisms. Within this pathway, patched functions as a receptor for the Hedgehog protein, regulating downstream signaling events. When Hedgehog binds to patched, it relieves the inhibitory effect of patched on another protein called Smoothened (SMO), leading to the activation of Hedgehog signaling.
Patched inhibitors work by specifically targeting the patched protein disrupting its interaction with Hedgehog and maintaining its inhibitory effect on SMO. By doing so, these inhibitors may modulate the Hedgehog signaling pathway, which could have implications for various developmental and cellular processes. Research into patched inhibitors is ongoing to unravel their mechanisms of action and explore their impact on Hedgehog signaling in different biological contexts. The study of patched inhibitors represents an intriguing area of research that may provide valuable insights into the regulation of Hedgehog signaling and its significance in various cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Binds to patched and inhibits its function as a receptor for Hedgehog (Hh) ligands, preventing the suppression of Smoothened (SMO). This leads to the activation of Hh signaling pathway and promotes cell proliferation and differentiation. Used in cancer therapy for Hedgehog pathway-dependent tumors. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Selective inhibitor of patched, binding to its extracellular domain and preventing its interaction with Hh ligands. This results in Hh pathway activation, leading to cell differentiation and growth inhibition in Hedgehog-dependent cancers. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Natural product that targets patched, binding to its transmembrane domain and inhibiting the interaction between patched and SMO. This leads to activation of Hh pathway and affects cell proliferation and differentiation in Hedgehog-dependent cancers. | ||||||
HPI-4 | 302803-72-1 | sc-358720 sc-358720A | 5 mg 25 mg | $136.00 $541.00 | ||
Inhibits patched by disrupting primary cilia formation, leading to activation of Hh signaling and affecting cell fate decisions during development and in cancer. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Antifungal drug that non-competitively inhibits patched, leading to the activation of Hh signaling pathway and inhibition of cancer cell growth in Hedgehog-dependent tumors. | ||||||
Saridegib | 1037210-93-7 | sc-507351 | 5 mg | $3500.00 | ||
Selective patched inhibitor that disrupts the patched-SMO interaction, leading to the activation of Hh signaling and inhibition of cancer cell proliferation in Hedgehog-dependent tumors. | ||||||
CUR 61414 | 334998-36-6 | sc-211143 | 1 mg | $380.00 | 1 | |
Small-molecule inhibitor of patched, leading to activation of Hh signaling and affecting cell proliferation and differentiation in Hedgehog-dependent cancers. | ||||||
Glasdegib | 1095173-27-5 | sc-507353 | 5 mg | $165.00 | ||
Also known as PF-04449913. Inhibits patched and activates Hh pathway by blocking patched-mediated SMO inhibition, leading to growth inhibition in Hedgehog-dependent cancers. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Induces patched degradation by promoting its phosphorylation and ubiquitination, leading to the activation of Hh signaling and influencing cell growth and differentiation. | ||||||
RU-SKI 43 | 1043797-53-0 | sc-507508 | 5 mg | $395.00 | ||
Inhibits patched by promoting its internalization and degradation, resulting in the activation of Hh signaling and affecting cell fate decisions during development and in cancer. | ||||||