PAT2 Inhibitors
PAT2 inhibitors are a class of chemical compounds specifically designed to target and modulate the activity of the PAT2 protein, also known as SLC36A2 (Solute Carrier Family 36 Member 2). PAT2, a member of the SLC36 family of transporters, plays a crucial role in cellular fatty acid and amino acid transport. These inhibitors are developed primarily for research purposes and are valuable tools for elucidating the physiological and pathological roles of PAT2 in various cellular processes.The mechanism of action of PAT2 inhibitors revolves around their ability to interfere with the function of the PAT2 protein. They typically do so by binding to specific regions of the protein or its associated regulatory elements, thereby inhibiting its transport function.
This inhibition can have profound effects on cellular lipid metabolism and amino acid transport. By blocking PAT2, these inhibitors allow researchers to investigate the consequences of altered fatty acid and amino acid uptake, which can lead to a better understanding of how these processes influence cell physiology and pathology. Additionally, PAT2 inhibitors are used in experimental setups to explore the interplay between PAT2 and other cellular components, shedding light on its broader significance in various biological contexts. Overall, PAT2 inhibitors serve as essential tools for researchers seeking to unravel the intricacies of fatty acid and amino acid transport, contributing to advancements in our knowledge of cellular biology and metabolic regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac inhibits PAT2 by interfering with its activity, leading to reduced fatty acid uptake into cells. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW9662 is a selective antagonist of PPARγ, a transcription factor that regulates PAT2 expression. Inhibition of PPARγ reduces PAT2 levels and function. It is a tool compound in research. | ||||||
(+)-Etomoxir sodium salt | 828934-41-4 | sc-215009 sc-215009A | 5 mg 25 mg | $148.00 $496.00 | 3 | |
Etomoxir inhibits carnitine palmitoyltransferase-1 (CPT-1), a key enzyme involved in fatty acid transport into mitochondria, thereby reducing PAT2-mediated fatty acid uptake. It is used in metabolic research. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole inhibits the proton pump (H+/K+ ATPase) in gastric parietal cells, reducing gastric acid production. This indirectly affects PAT2 by altering gastric pH and digestion. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can indirectly affect PAT2 function by interfering with signaling pathways involved in its regulation. It is a dietary isoflavone with potential health benefits. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a multi-kinase inhibitor that can impact PAT2 indirectly by modulating signaling pathways. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone is a PPARγ agonist that can affect PAT2 expression by activating PPARγ, which in turn regulates genes involved in fatty acid transport. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Triclosan disrupts bacterial fatty acid synthesis, which may indirectly impact PAT2 by altering the composition of gut microbiota and metabolic processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which can modulate PAT2 indirectly by regulating cellular energy homeostasis and lipid metabolism. It is used in cellular and metabolic research. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $224.00 $414.00 | ||
Pyrvinium pamoate inhibits mitochondrial respiration and induces mitochondrial stress, potentially impacting PAT2-mediated fatty acid transport. | ||||||