PARP-10 Inhibitors
The chemical class designated as PARP-10 Inhibitors is made up of small molecules that target various members of the PARP family, which could indirectly affect the function of PARP-10. These inhibitors share the commonality of being able to bind to the catalytic domain of PARP enzymes, which is essential for their enzymatic activity, including the transfer of ADP-ribose units to target proteins. The inhibition of this domain can result in the suppression of the protein's ability to modify itself and other proteins, a key step in processes like DNA repair and signaling.
Compounds such as Olaparib, Veliparib, Niraparib, Rucaparib, and Talazoparib are well-known for their higher selectivity towards PARP1 and PARP2 but can exhibit effects on other PARP family members due to the conserved nature of the PARP domain. These inhibitors work by mimicking the nicotinamide portion of NAD+ and binding to the catalytic site, thereby preventing the necessary conformational changes for catalysis. Other chemicals like 3-aminobenzamide (3AB) and PJ34 are less selective and may influence PARP-10 by broadly targeting the PARP enzymatic activity. NU1025 and AG14361, while more selective towards PARP1, may have off-target effects on PARP-10, considering the structural similarities within the catalytic domains of PARP proteins
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
A PARP family inhibitor that can inhibit the enzymatic activity of PARP-10 by blocking the PARP domain common to the family. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $178.00 $270.00 $712.00 | 3 | |
Another PARP inhibitor that can bind to the catalytic site of PARP enzymes, possibly affecting PARP-10. | ||||||
Niraparib | 1038915-60-4 | sc-507492 | 10 mg | $150.00 | ||
A selective inhibitor of PARP1 and PARP2 that may have off-target effects on PARP-10 due to structural similarities. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
A potent inhibitor of PARP1 and PARP2, with potential to inhibit PARP-10 by targeting the ADP-ribosyltransferase domain. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
A PARP inhibitor with a strong trapping potential that might affect PARP-10's activity indirectly. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $36.00 $51.00 | 18 | |
A general PARP inhibitor that may reduce PARP-10's ADP-ribosylation activity non-selectively. | ||||||
IEM 1754 dihydrobromide | 162831-31-4 | sc-362747 sc-362747A | 10 mg 50 mg | $172.00 $729.00 | ||
A broad-spectrum PARP inhibitor that could decrease PARP-10 activity by blocking NAD+ binding sites. | ||||||
NU 1025 | 90417-38-2 | sc-203166 | 5 mg | $131.00 | 9 | |
A specific PARP-1 inhibitor that might affect PARP-10 indirectly due to structural homology. | ||||||
AG14361 | 328543-09-5 | sc-483192 | 5 mg | $255.00 | ||
A selective PARP-1 inhibitor which could inhibit PARP-10 by binding to the catalytic domain. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $270.00 $320.00 $600.00 | 3 | |
A derivative of benzimidazole that acts as a PARP inhibitor and could influence PARP-10's function. | ||||||