PARP-10 Activators
Poly (ADP-ribose) polymerase 10 (PARP-10) is a member of the PARP family of enzymes, which play pivotal roles in various cellular processes, including DNA repair, genomic stability, and cell death. PARP-10, in particular, has garnered attention due to its involvement in the intricate network of signaling pathways responsible for maintaining DNA integrity. As cellular mechanisms detect and respond to genotoxic stress, PARP-10 expression can be induced, suggesting a potential regulatory role in the cellular stress response. This induction is an integral part of the cell's endogenous efforts to manage and rectify the consequences of DNA damage, highlighting PARP-10's significance in the cellular arsenal against genetic insults.
Certain chemicals have been identified as potential activators of PARP-10 expression due to their influence on cellular pathways that are closely linked with the DNA damage response (DDR). For instance, compounds that inflict direct DNA damage, such as doxorubicin and cisplatin, lead to the activation of the DDR, which may include the upregulation of PARP-10 as the cell mobilizes to repair the damaged DNA. Similarly, agents that create an environment of oxidative stress, like hydrogen peroxide, can instigate a cellular response that favors the upregulation of DNA repair proteins, including PARP-10, to counteract oxidative DNA lesions. Furthermore, molecules like resveratrol and niacin, which modulate metabolic states and influence cellular defenses against stress, could also contribute to an increase in PARP-10 expression. The interplay between these compounds and PARP-10 underscores the dynamic nature of intracellular repair processes, wherein PARP-10 upregulation serves as a barometer of the cell's endeavor to preserve genomic fidelity in the face of diverse chemical stresses.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to activate SIRT1, a NAD+-dependent deacetylase, which can lead to the activation of the DNA repair machinery and potentially stimulate the upregulation of PARP10 as part of the cellular reparative response to oxidative stress and damage. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, by inhibiting histone deacetylases, promotes hyperacetylation of histones, thereby unwinding DNA and granting access for transcription factors. This can lead to the enhanced transcription of DNA repair genes, including the potential upregulation of PARP10 to respond to the altered chromatin landscape and cellular homeostasis. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
Nicotinic Acid, through its role as a precursor in the biosynthesis of NAD+, can increase the cellular pool of this coenzyme, which is essential for PARP enzyme activity. Elevated NAD+ levels can serve as a signal for cells to bolster their DNA repair capabilities, potentially stimulating an increase in PARP10 synthesis to meet the augmented demand for PARP activity. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and interferes with the replication and transcription processes, precipitating a need for DNA repair. This can lead to the activation of the DNA damage response (DDR) pathways, which often includes the upregulation of PARP10 as a component of the cellular effort to rectify doxorubicin-induced DNA damage. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
Methyl Methanesulfonate alkylates DNA bases, which can lead to erroneous base pairing and DNA breaks. Cells respond to such genotoxic stress by augmenting the expression of DNA repair proteins, including PARP10, to counteract the genomic insults inflicted by MMS and maintain genomic stability. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide generates reactive oxygen species that can damage cellular components, including DNA. The oxidative stress response often entails the induction of antioxidant defenses and DNA repair proteins. PARP10 expression may be upregulated as part of this response to counteract the damage and assist in the repair of oxidized DNA bases. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been reported to stimulate the expression of a variety of stress response genes. Its role in enhancing the cellular defense mechanisms against oxidative stress and inflammation could potentially lead to the upregulation of PARP10 as a protective measure to ensure the integrity of cellular genetic material. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $89.00 $250.00 | 32 | |
Temozolomide induces methyl adducts on DNA, most notably at the O6 position of guanine, leading to mispairing and DNA strand breaks. The DDR to temozolomide-induced lesions may include the upregulation of PARP10 as part of a coordinated response to maintain cell survival and genome integrity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin forms intrastrand and interstrand DNA cross-links that impede transcription and replication. The subsequent DDR is complex, involving the transcriptional upregulation of various DNA repair genes. PARP10 expression could be stimulated as the cell mobilizes its repair processes to mitigate cisplatin-induced cytotoxicity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide stabilizes the DNA-topoisomerase II complex after it has broken the DNA strand for replication, preventing the religation of these strands and leading to double-strand breaks. The cell's response to this damage may include the upregulation of PARP10 to facilitate DNA repair processes and reestablish chromosomal integrity. | ||||||