Date published: 2026-4-23

1-800-457-3801

SCBT Portrait Logo
Seach Input

Cisplatin (CAS 15663-27-1)

4.0(4)
Write a reviewAsk a question

See product citations (101)

Alternate Names:
Cisplatin also known as CDDP; cis-Diammineplatinum(II) dichloride; Cisplatinum; Blastolem; Briplatin; Cisplatyl; Neoplatin; Platinex; cis-Diamminedichloroplatinum(II) Platiblastin; Platosin; Lederplatin; Platinoxan; CDDP; CACP; CPDC; cis-DDP Platamine; Platinol
Application:
Cisplatin is a potent platinum-based anti-neoplastic agent which is used as an apoptosis inducer and caspase-3 activator
CAS Number:
15663-27-1
Purity:
≥99%
Molecular Weight:
300.05
Molecular Formula:
H6Cl2N2Pt
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Cisplatin is a platinum-containing compound with significant applications in biochemical and cancer research. It functions by inducing cross-links within and between DNA strands, which disrupts DNA synthesis and transcription, leading to cell cycle arrest and apoptosis. In research, cisplatin is used to study the cellular responses to DNA damage and the mechanisms of DNA repair. Its effectiveness in causing DNA lesions makes it useful for examining the pathways that cells use to maintain genetic integrity. Studies involving cisplatin have provided insights into the molecular basis of cell death and the survival mechanisms employed by cancer cells, including the roles of various DNA repair proteins and signaling pathways in determining cell fate. Research with cisplatin also contributes to the understanding of chemical resistance mechanisms, as cancer cells can develop resistance to DNA-damaging agents over time.


Cisplatin (CAS 15663-27-1) References

  1. Biomolecular targets for platinum antitumor drugs.  |  Bose, RN. 2002. Mini Rev Med Chem. 2: 103-11. PMID: 12370072
  2. Cisplatin: mode of cytotoxic action and molecular basis of resistance.  |  Siddik, ZH. 2003. Oncogene. 22: 7265-79. PMID: 14576837
  3. Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.  |  van Waardenburg, RC., et al. 2004. J Biol Chem. 279: 54502-9. PMID: 15471886
  4. Systemic Delivery and Biodistribution of Cisplatin in Vivo.  |  Chu, YH., et al. 2016. Mol Pharm. 13: 2677-82. PMID: 27299507
  5. Immune response of mice exposed to cis-diamminedichloroplatinum.  |  Bagasra, O., et al. 1985. Cancer Immunol Immunother. 19: 142-7. PMID: 3157438
  6. Retinoic acid receptor-beta prevents cisplatin-induced proximal tubular cell death.  |  Yago-Ibáñez, J., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165795. PMID: 32278009
  7. Nanotechnology-Based Cisplatin Intracellular Delivery to Enhance Chemo-Sensitivity of Ovarian Cancer.  |  Bortot, B., et al. 2020. Int J Nanomedicine. 15: 4793-4810. PMID: 32764921
  8. Changing the time intervals between cisplatin cycles alter its ototoxic side effect.  |  Bielefeld, EC., et al. 2021. Hear Res. 404: 108204. PMID: 33618164
  9. Using a High Quantum Yield Fluorescent Probe with Two-Photon Excitation to Detect Cisplatin in Biological Systems.  |  Fan, F., et al. 2021. ACS Sens. 6: 1400-1406. PMID: 33656320
  10. Ameliorative Effects of Gallic Acid on Cisplatin-Induced Nephrotoxicity in Rat Variations of Biochemistry, Histopathology, and Gene Expression.  |  Eslamifar, Z., et al. 2021. Biomed Res Int. 2021: 2195238. PMID: 34746299
  11. Cisplatin fastens chromatin irreversibly even at a high chloride concentration.  |  Moon, HM., et al. 2021. Nucleic Acids Res. 49: 12035-12047. PMID: 34865121
  12. The optimum inhibitory effects of Alpha Interferon and Cisplatin in colon cancer, a comparative in vitro study.  |  Muttar, A., et al. 2022. J Med Life. 15: 269-277. PMID: 35419098
  13. Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice.  |  Gales, A., et al. 2022. Can J Physiol Pharmacol. 100: 868-879. PMID: 35704945
  14. One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer.  |  Steenbrugge, J., et al. 2022. Oncoimmunology. 11: 2103277. PMID: 35898705

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cisplatin, 100 mg

sc-200896
100 mg
$138.00

Cisplatin, 500 mg

sc-200896A
500 mg
$380.00

可以用于诱导蜕膜细胞凋亡吗?

Asked by: AAAI
Thank you for your inquiry. Please contact our Technical Service Department. Our Asian Technical Service team is available at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website. 感谢您的提问。请联系我们的技术支持部门。亚洲技术支持电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”。
Answered by: Yanru Tao
Date published: 2022-07-12

what is good solvent? ex) DMSO, 3.D.W

Asked by: ami204
Thank you for your question. Cisplatin (CAS 15663-27-1) sc-200896 is soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
Answered by: Tech Support Europe
Date published: 2019-06-19

If mixed with DMSO how should it be stored? for long term storage?

Asked by: rpdee
Thank you for your question. DMSO is not a recommended solvent for Cisplatin. The divalent platinum has a high affinity for sulfur donor ligands and this will displace the chloride. The use of DMSO as a solvent affects the instability of cisplatin and can affect biological activity. Sundquist, W. I., et al., Inorg. Chem. 26:1524-1528, 1987.
Answered by: Technical Support
Date published: 2023-07-17

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, is in yellow crystalline powder form.
Answered by: Chemical Support 4
Date published: 2018-11-06

Is it HPLC grade?

Asked by: chemsd02
Thank you for your question. Yes, sc-200896 (Cisplatin, CAS 15663-27-1) is HPLC grade.
Answered by: Chemical Support 10
Date published: 2021-05-17

From the website: material is soluble in water at 0.25g/100ml in 25℃. How long can it be stocked? Can it be stable for at least one year? Should I adjust its pH? Thank you!

Asked by: two2igm05
Thank you for your question. Cisplatin, sc-200896, can be stored for 3 years at -20℃ as a powder and for 6 months at -80℃ in solvent.
Answered by: TechService7
Date published: 2016-12-21
  • y_2026, m_4, d_23, h_7CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_6
  • loc_en_US, sid_200896, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 103ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from CDDPThis agent worked perfectly in cell viability assay
Date published: 2022-08-04
Rated 1 out of 5 by from Dissolving issuesEven though it is highly recommended not to dissolve cisplatin in DMSO, it seems that it is the only solvent that it dissolves in. Please recommend solvents that will dissolve cisplatin as water is not appropriate.
Date published: 2021-02-02
Rated 5 out of 5 by from We used this in different human cell linesWe used this in different human cell lines and works well for our study.
Date published: 2015-10-06
Rated 5 out of 5 by from ChenChen, et. al. (PubMed ID 17651689) report that nuclear Trx-1 is required by MCF-7 cells to resist apoptosis when induced by cisplatin. They extrapolate based on this finding that this resistance most likely occurs through the up-regulation of p53 (the anti-apoptotic gene). -SCBT Publication Review
Date published: 2015-04-10
  • y_2026, m_4, d_23, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_200896, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
Cisplatin is rated 4.0 out of 5 by 4.
  • y_2026, m_4, d_23, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_en_US, sid_200896, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 107ms
  • REVIEWS, PRODUCT