PARP-1 Inhibitors
Items 21 to 26 of 26 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PARP Inhibitor IX, EB-47 | 366454-36-6 | sc-222125 | 1 mg | $182.00 | 2 | |
PARP Inhibitor IX, EB-47, exhibits a distinctive mechanism of action through its selective binding to PARP-1, facilitated by a network of electrostatic interactions and π-π stacking. The compound's unique structural motifs enhance its affinity, allowing it to effectively disrupt the enzyme's catalytic activity. Its kinetic properties suggest a rapid association and dissociation rate, which may influence the overall cellular response. Additionally, the presence of specific functional groups may modulate its interaction dynamics, impacting the enzyme's regulatory pathways. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
Talazoparib tosylate is a PARP inhibitor that has shown efficacy in research studies against various cancers, including breast and ovarian cancers. | ||||||
TIQ-A | 420849-22-5 | sc-204916 sc-204916A | 1 mg 5 mg | $68.00 $282.00 | 1 | |
TIQ-A functions as a PARP-1 inhibitor by engaging in specific hydrogen bonding and hydrophobic interactions that stabilize its binding to the enzyme. Its unique conformation allows for a precise fit within the active site, effectively obstructing the enzyme's function. The compound's reaction kinetics indicate a slow onset of inhibition, which may lead to prolonged effects on cellular processes. Furthermore, its distinct electronic properties can influence the redox state of nearby residues, potentially altering enzymatic pathways. | ||||||
4-HQN | 491-36-1 | sc-200129 | 5 g | $32.00 | ||
4-HQN acts as a PARP-1 inhibitor through its ability to form strong π-π stacking interactions with aromatic residues in the enzyme's active site. This compound exhibits a unique binding affinity that enhances its selectivity, allowing for a more effective blockade of PARP-1 activity. Additionally, its structural flexibility contributes to a dynamic interaction profile, influencing the enzyme's conformational states and potentially modulating downstream signaling pathways. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
Veliparib functions as a PARP-1 inhibitor by engaging in hydrogen bonding and hydrophobic interactions with key amino acid residues within the enzyme's active site. Its unique structural features allow for a high degree of specificity, facilitating a robust inhibition mechanism. The compound's kinetic profile reveals a rapid association and dissociation rate, which may influence the enzyme's catalytic efficiency and alter the dynamics of DNA repair pathways. | ||||||
Paraxanthine | 611-59-6 | sc-212526A sc-212526B sc-212526 sc-212526C sc-212526D sc-212526E | 25 mg 50 mg 100 mg 250 mg 500 mg 1 g | $183.00 $247.00 $339.00 $693.00 $1169.00 $2035.00 | 2 | |
Paraxanthine acts as a PARP-1 inhibitor through its ability to form stable complexes with the enzyme, primarily via π-π stacking and van der Waals interactions. This compound exhibits a unique conformational flexibility that enhances its binding affinity, allowing it to effectively disrupt the enzyme's function. Its reaction kinetics indicate a moderate inhibition rate, which can modulate the cellular response to DNA damage, impacting repair mechanisms at a molecular level. | ||||||