Molecular structure of Paraxanthine, CAS Number: 611-59-6
Paraxanthine (CAS 611-59-6)
See product citations (2)
Alternate Names:
1,7-Dimethylxanthine
Application:
Paraxanthine is an adenosine receptor ligand and a major metabolite of caffeine
CAS Number:
611-59-6
Purity:
≥97%
Molecular Weight:
180.16
Molecular Formula:
C7H8N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Paraxanthine is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-alpha and leukotriene synthesis. In addition, Paraxanthine acts as a Na+/K+ ATPase enzymatic effector.
Paraxanthine (CAS 611-59-6) References
- Cyclic nucleotide phosphodiesterases. | Essayan, DM. 2001. J Allergy Clin Immunol. 108: 671-80. PMID: 11692087
- Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. | Guerreiro, S., et al. 2008. Mol Pharmacol. 74: 980-9. PMID: 18621927
- Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine. | Geraets, L., et al. 2010. Eur J Pharmacol. 629: 132-9. PMID: 19962977
- Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes. | Ferré, S., et al. 1990. Eur J Pharmacol. 179: 295-9. PMID: 2194822
- Paraxanthine: Connecting Caffeine to Nitric Oxide Neurotransmission. | Ferré, S., et al. 2013. J Caffeine Res. 3: 72-78. PMID: 24761277
- Simultaneous Quantification of Antioxidants Paraxanthine and Caffeine in Human Saliva by Electrochemical Sensing for CYP1A2 Phenotyping. | Anastasiadi, RM., et al. 2020. Antioxidants (Basel). 10: PMID: 33374269
- The determination of the Paraxanthine/Caffeine ratio as a metabolic biomarker for CYP1A2 activity in various human matrices by UHPLC-ESIMS/MS. | Lajin, B., et al. 2021. Talanta. 234: 122658. PMID: 34364467
- Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice. | Jäger, R., et al. 2022. Nutrients. 14: PMID: 35215543
- A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. | Matsumura, N., et al. 2023. J Pharmacol Sci. 151: 37-45. PMID: 36522121
- Paraxanthine safety and comparison to caffeine. | Szlapinski, SK., et al. 2023. Front Toxicol. 5: 1117729. PMID: 36818692
- Determination of caffeine, paraxanthine, theophylline and theobromine in premature infants by HILIC-MS/MS. | Wen, SY., et al. 2022. Bioanalysis. 14: 1497-1508. PMID: 36825935
- Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum. | Jiang, M., et al. 1998. Planta Med. 64: 375-7. PMID: 9619123
- Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. | Marques, LJ., et al. 1999. Am J Respir Crit Care Med. 159: 508-11. PMID: 9927365
Inhibitor of:
PARP-1, and PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Paraxanthine, 25 mg | sc-212526A | 25 mg | $179.00 | |||
Paraxanthine, 50 mg | sc-212526B | 50 mg | $242.00 | |||
Paraxanthine, 100 mg | sc-212526 | 100 mg | $332.00 | |||
Paraxanthine, 250 mg | sc-212526C | 250 mg | $679.00 | |||
Paraxanthine, 500 mg | sc-212526D | 500 mg | $1169.00 | |||
Paraxanthine, 1 g | sc-212526E | 1 g | $1995.00 |