PARL Activators
PARL activators, also known as presenilin-associated rhomboid-like protein activators, are a class of small molecules that have gained significant attention in the field of molecular biology and cellular physiology. These compounds are specifically designed to target and modulate the activity of the PARL enzyme, a member of the rhomboid protease family located within the inner mitochondrial membrane. The primary function of PARL activators is to influence the proteolytic activity of PARL, thereby affecting various cellular processes associated with mitochondrial function, cellular metabolism, and the regulation of apoptosis.
PARL, as a mitochondrial protease, plays a crucial role in the processing and cleavage of specific substrates within the mitochondria. It is responsible for the proteolytic maturation of proteins involved in mitochondrial dynamics, including fusion and fission events, as well as the regulation of mitophagy, a process of selective removal of damaged mitochondria. PARL activators are designed to modulate the activity of this enzyme, either by enhancing or inhibiting its proteolytic functions. By doing so, they can impact the overall health and functionality of mitochondria within a cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
CCCP is a chemical compound that disrupts the mitochondrial membrane potential, leading to the activation of PARL. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
Similar to CCCP, FCCP is a mitochondrial uncoupler that can activate PARL by disrupting mitochondrial function. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $163.00 | 3 | |
Valinomycin is an ionophore that disrupts the mitochondrial membrane potential, leading to the activation of PARL. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
DNP is another mitochondrial uncoupler that can activate PARL by dissipating the proton gradient across the mitochondrial inner membrane. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of complex I in the electron transport chain and can activate PARL by interfering with mitochondrial electron transport. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that can disrupt mitochondrial calcium homeostasis and activate PARL. | ||||||