PARD6A Activators
PARD6A activators belong to a class of chemical compounds that exert their effects on the PARD6A protein, which is a critical component of the Par complex involved in cell polarity regulation. PARD6A, short for Partitioning-Defective 6 Homolog Alpha, plays a pivotal role in the establishment and maintenance of cellular asymmetry, a fundamental process in various physiological and developmental contexts. This class of activators, typically small molecules or peptides, modulates PARD6A's activity and function, contributing to the intricate machinery governing cellular organization and behavior.
PARD6A activators act by directly binding to the PARD6A protein, thereby altering its conformation or promoting its interaction with other cellular components. These compounds can have a profound impact on cellular processes such as cell division, migration, and differentiation, as PARD6A is involved in establishing cellular polarity cues and coordinating the asymmetric distribution of cellular components. By targeting PARD6A, activators may influence the orientation of cell division, cell movement, and the sorting of specific molecules within cells, all of which are crucial for the proper development and functioning of various tissues and organs. Understanding the mechanisms of PARD6A activation and its downstream effects is of great interest in the field of cell biology and developmental biology, as it sheds light on the fundamental principles underlying tissue organization and morphogenesis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
It can modulate gene expression through retinoic acid receptors, potentially increasing PARD6A transcription in certain cell types. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium impacts Wnt signaling pathway, which could increase the expression of genes involved in cell polarity such as PARD6A. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By elevating cAMP levels, forskolin can activate PKA and subsequently may enhance PARD6A expression through cAMP response element-binding proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which may result in the induction of PARD6A as part of the response to altered cell signaling. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
It acts on glucocorticoid receptors, which may lead to transcriptional changes including the upregulation of PARD6A expression. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
As an oxidative stress agent, it can activate various signaling pathways, potentially increasing the expression of genes like PARD6A. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate inhibits histone deacetylase, which may result in hyperacetylation of histones and activation of PARD6A expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
It engages with its nuclear receptor, influencing the transcription of target genes, which could include the upregulation of PARD6A. | ||||||