PARD6A Inhibitors
PARD6A inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of the protein known as Partitioning-defective 6 homolog alpha (PARD6A). PARD6A is a crucial component of the Par complex, which plays a pivotal role in the establishment of cell polarity, a fundamental process in cell biology. Cell polarity is vital for various cellular functions, including cell division, migration, and differentiation. The Par complex, where PARD6A is a key member, is involved in organizing cellular components, ensuring that they are distributed correctly within the cell. Chemical compounds classified as PARD6A inhibitors are designed to interfere with the normal function of PARD6A by binding to it or altering its activity. This inhibition can disrupt the assembly of the Par complex and consequently affect the establishment of cell polarity.
While the specific mechanisms of action may vary among different PARD6A inhibitors, their common goal is to perturb the interactions and functions of PARD6A within the cell. By doing so, these inhibitors offer researchers valuable tools for studying the molecular processes underlying cell polarity and related cellular phenomena in various contexts, including cell culture experiments and research. In summary, PARD6A inhibitors constitute a chemical class designed to target the PARD6A protein, a crucial player in the establishment of cell polarity. These inhibitors can be instrumental in elucidating the intricate mechanisms governing cellular organization and polarity, thereby advancing our understanding of fundamental cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is known to inhibit DNA methyltransferases, potentially leading to reduced methylation of the PARD6A promoter, which could decrease its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, it may increase histone acetylation, potentially leading to a more open chromatin structure and reduced PARD6A expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2′-Deoxycytidine inhibits DNA methyltransferases, potentially decreasing PARD6A expression through reduced promoter methylation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
As a histone deacetylase inhibitor, it can increase histone acetylation and potentially lead to decreased PARD6A expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
It is another histone deacetylase inhibitor, which might result in increased histone acetylation and reduced PARD6A expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known to modulate various signaling pathways, it might decrease PARD6A expression through its anti-inflammatory and antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
It is known for its ability to modulate multiple cellular processes and might decrease PARD6A expression through its anti-inflammatory effects. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, it may reduce PARD6A expression through its ability to activate antioxidant response elements. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
As a flavonoid with antioxidant properties, it might modulate various signaling pathways, potentially leading to reduced PARD6A expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, it might decrease PARD6A expression by inhibiting pathways that are crucial for its expression. | ||||||