PABPNL1 Activators
PABPN1L activators encompass a diverse group of chemicals that can influence the activity of the poly(A) binding protein, nuclear 1-like (PABPN1L), which plays a role in RNA metabolism, particularly in the modulation of mRNA processing. This chemical class is characterized by their ability to impact various cellular signaling pathways and molecular processes that are associated with the regulation of gene expression, mRNA stability, and translation. By affecting these fundamental cellular mechanisms, these activators can alter the functional dynamics of PABPN1L. The chemicals in this category can work through indirect mechanisms, such as the modulation of enzymatic activity that relates to the synthesis of secondary messengers, the alteration of transcription factors, or the inhibition of protein degradation pathways. These activators can lead to changes in the phosphorylation patterns of proteins, the acetylation state of histones affecting chromatin structure, or the methylation of DNA, all of which can have downstream effects on the activity of proteins involved in mRNA processing.
Moreover, the activators within this class can impact the protein's function by stabilizing interacting molecules or by shifting the equilibrium of cellular stress responses that are often tightly linked to RNA metabolic processes. By influencing the spliceosomal machinery, they can also change the splicing patterns of pre-mRNAs, which in turn may affect the activity of PABPN1L. In addition, by modulating the activity of various signal transduction pathways, these chemicals can lead to an adjusted cellular environment that supports the enhanced function of PABPN1L. Overall, the class of PABPN1L activators is defined by their capacity to interact with and modulate the complex network of cellular components and pathways that govern the life cycle of mRNA, from its synthesis and processing to its eventual translation, thereby influencing the activity of PABPN1L within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases intracellular cAMP levels and can lead to the activation of PKA. PKA can phosphorylate various proteins involved in mRNA processing and translation, which could possibly activate PABPN1L. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which prevents cAMP breakdown, thereby sustaining PKA activity and could possibly activate PABPN1L by enhancing the phosphorylation status of proteins involved in mRNA metabolism. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can modulate various signaling pathways, including those related to cell stress and apoptosis. It could possibly activate PABPN1L by affecting mRNA stability and translation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium has been shown to activate the Wnt/β-catenin pathway, which is implicated in the regulation of gene expression and could possibly activate PABPN1L by affecting proteins involved in mRNA processing. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that could possibly activate PABPN1L by leading to a more relaxed chromatin structure, enhancing transcription and potentially affecting the expression and function of mRNA processing proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Similar to sodium butyrate, Trichostatin A inhibits histone deacetylases and could possibly activate PABPN1L by affecting transcriptional profiles and influencing proteins involved in mRNA metabolism. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that alters gene expression and could possibly activate PABPN1L by changing the cellular transcriptome. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that could possibly activate PABPN1L by stabilizing proteins, preventing their degradation, and resulting in the accumulation of regulatory factors that modulate mRNA processing activities. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that could possibly activate PABPN1L by leading to a decrease in cap-dependent translation initiation, potentially causing a compensatory mechanism that enhances the role of proteins in mRNA processing. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting transcription. This reduction in mRNA synthesis could possibly activate PABPN1L due to changes in the pool of mRNAs requiring processing. | ||||||