Date published: 2025-12-18

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p38 α Activators

Santa Cruz Biotechnology now offers a broad range of p38 alpha Activators for use in various applications. p38 alpha Activators target the p38 alpha mitogen-activated protein kinase (MAPK), a critical enzyme involved in cellular responses to stress, inflammation, and environmental signals. By activating p38 alpha, researchers can delve into the intricate signaling pathways that regulate crucial cellular processes such as apoptosis, differentiation, and autophagy. These activators are invaluable tools for investigating the role of p38 alpha in the MAPK signaling cascade, offering insights into how cells respond to various stimuli like cytokines, oxidative stress, and osmotic changes. Utilizing p38 alpha Activators allows scientists to study the activation of downstream targets and the subsequent biological effects, including changes in gene expression, protein synthesis, and cellular metabolism. These activators are particularly useful in exploring the mechanisms of cellular stress responses and the regulation of inflammatory pathways, providing a deeper understanding of the molecular basis of stress adaptation and resilience. Moreover, p38 alpha Activators facilitate the study of protein-protein interactions and phosphorylation events, shedding light on the dynamic processes that govern cell fate and function. Researchers use these activators to study the cross-talk between different signaling networks and to dissect the complex web of regulatory mechanisms that maintain cellular homeostasis and adaptability. The ability to precisely modulate p38 alpha activity is crucial for advancing our knowledge of cell biology and signaling dynamics in various experimental contexts. View detailed information on our available p38 alpha Activators by clicking on the product name.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Angiotensin II, Human

4474-91-3sc-363643
sc-363643A
sc-363643B
sc-363643C
1 mg
5 mg
25 mg
100 mg
$50.00
$75.00
$260.00
$505.00
3
(1)

Angiotensin II, Human, as a p38 alpha, exhibits a unique ability to engage in specific protein-protein interactions, influencing downstream signaling pathways. Its structural conformation allows for selective binding to receptor sites, triggering distinct cellular responses. The compound's dynamic behavior in aqueous environments enhances its reactivity, while its affinity for certain kinases underscores its role in modulating cellular stress responses and inflammatory processes.

Nicotinamide

98-92-0sc-208096
sc-208096A
sc-208096B
sc-208096C
100 g
250 g
1 kg
5 kg
$43.00
$65.00
$200.00
$815.00
6
(1)

Nicotinamide, as a p38 alpha, demonstrates a remarkable capacity for modulating enzymatic activity through its interactions with key regulatory proteins. Its unique structural features facilitate the formation of hydrogen bonds, enhancing its binding affinity to target sites. This compound plays a critical role in cellular energy metabolism, influencing the kinetics of various biochemical pathways. Additionally, its solubility in polar solvents allows for efficient diffusion within cellular environments, promoting rapid physiological responses.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$97.00
$254.00
36
(2)

Anisomycin can activate p38α via cellular stress, specifically by inhibiting protein synthesis.

SH-5

sc-205973
sc-205973A
0.5 mg
1 mg
$151.00
$256.00
3
(1)

SH-5, functioning as a p38 alpha, exhibits distinctive molecular interactions that enhance its specificity for target kinases. Its unique conformation allows for effective steric hindrance, influencing the phosphorylation of downstream substrates. The compound's reactivity profile is characterized by rapid kinetics, facilitating swift modulation of signaling cascades. Furthermore, SH-5's hydrophobic regions contribute to its membrane permeability, enabling efficient cellular uptake and localized action within complex biological systems.

Sodium (meta)arsenite

7784-46-5sc-250986
sc-250986A
100 g
1 kg
$106.00
$765.00
3
(2)

Sodium arsenite induces oxidative stress, leading to the activation of p38α.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

Induces oxidative stress, which can activate p38α.

C2 Ceramide

3102-57-6sc-201375
sc-201375A
5 mg
25 mg
$77.00
$316.00
12
(1)

C2 Ceramide can activate p38α by inducing cellular stress and activating the SAPK pathway.

Cadmium chloride, anhydrous

10108-64-2sc-252533
sc-252533A
sc-252533B
10 g
50 g
500 g
$55.00
$179.00
$345.00
1
(1)

Activates p38α by inducing oxidative stress.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$94.00
$349.00
114
(2)

Induces ER stress, leading to the activation of p38α.

Isoproterenol Hydrochloride

51-30-9sc-202188
sc-202188A
100 mg
500 mg
$27.00
$37.00
5
(0)

Activates β-adrenergic receptors, leading to PKA activation and subsequent p38α activation.