SH-5

5.0(1)

Alternate Names: Akt Inhibitor II; D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]

Application: SH-5 is an Inhibitor of Akt activation

Purity: ≥98%

Molecular Weight: 598.75

Molecular Formula: C₂₉H₅₉O₁₀P

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SH-5 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. SH-5 induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival. SH-5 is an activator of p38 alpha.

References

1. Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc. 125: 1144-1145. PMID: 12553797

Physical State :

Solid

Solubility :

Soluble in DMSO (10 mg/ml), methanol, and water (slightly).

Storage :

Store at 4° C

Boiling Point :

~670.3° C at 760 mmHg (Predicted)

Density :

~1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.50 (Predicted)

pK Values :

pK_a: 1.39 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

9938589

MDL Number :

MFCD08703608

SMILES :

CCCCCCCCCCCCCCCCCCOC[[email protected]](COP(=O)(O)O[[email protected]@H]1[[email protected]@H](C[[email protected]]([[email protected]@H]([[email protected]]1O)O)O)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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SH-5 Product Citations

See how others have used SH-5. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 33673180 Hao, L.|Marshall, AJ.|Liu, L.| et al. 2021. Int J Mol Sci. 22:

PMID: # 30505322 Cell Mol Biol Lett. 55.

Citations 1 to 3 of 3 total

Rated 5 out of 5 by TS from Chien et al Chien et al, (PubMed ID 26385185) used SH-5 to inhibit CORM-2-induced HO-1 protein expression in primary human cardiomyocytes via Akt inactivation. -SCBT Publication Review

Date published: 2015-07-20

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