SH-5 MF: C29H59O10P
MW: 598.75
An Inhibitor of Akt activation.

SH-5

SH-5 is rated 5.0 out of 5 by 1.
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Alternate Names: Akt Inhibitor II; D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Application: SH-5 is an Inhibitor of Akt activation
Purity: ≥98%
Molecular Weight: 598.75
Molecular Formula: C29H59O10P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SH-5 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. SH-5 induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival. SH-5 is an activator of p38 alpha.


References

1. Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc. 125: 1144-1145. PMID: 12553797

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), methanol, and water (slightly).
Storage :
Store at 4° C
Boiling Point :
~670.3° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.50 (Predicted)
pK Values :
pKa: 1.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD08703608
SMILES :

Download SDS (MSDS)

Certificate of Analysis

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SH-5  Product Citations

See how others have used SH-5. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 33673180  Hao, L.|Marshall, AJ.|Liu, L.| et al. 2021. Int J Mol Sci. 22:

PMID: # 25931510  Reddy, GR.|Subramanian, H.|Birk, A.|Milde, M.|Nikolaev, VO.|Bünemann, M.| et al. 2015. FASEB J. 29: 3458-71.

PMID: # 30505322  Cell Mol Biol Lett. 55.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Chien et al Chien et al, (PubMed ID 26385185) used SH-5 to inhibit CORM-2-induced HO-1 protein expression in primary human cardiomyocytes via Akt inactivation. -SCBT Publication Review
Date published: 2015-07-20
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