Molecular structure of SH-5
SH-5
See product citations (3)
Alternate Names:
Akt Inhibitor II; D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Application:
SH-5 is an Inhibitor of Akt activation
Purity:
≥98%
Molecular Weight:
598.75
Molecular Formula:
C29H59O10P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SH-5 is an inhibitor of Akt (PKB) activation without affecting activation of the upstream kinase PDK-1, or other kinases downstream of Ras such as MAPK. SH-5 induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt and depending upon Akt for survival. SH-5 is an activator of p38 alpha.
SH-5 References
- Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. | Kozikowski, AP., et al. 2003. J Am Chem Soc. 125: 1144-5. PMID: 12553797
- Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway. | Lu, Y. and Wahl, LM. 2005. J Leukoc Biol. 78: 259-65. PMID: 15800029
- C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1. | Fosbrink, M., et al. 2006. J Biol Chem. 281: 19009-18. PMID: 16670089
- SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. | Sethi, G., et al. 2008. Biochem Pharmacol. 76: 1404-16. PMID: 18606397
- 4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways. | Lee, SJ., et al. 2008. Free Radic Biol Med. 45: 1487-92. PMID: 18805481
- Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation. | Slomiany, BL. and Slomiany, A. 2010. Mediators Inflamm. 2010: 280464. PMID: 20369000
- Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations. | Krech, T., et al. 2010. BMC Cancer. 10: 287. PMID: 20546605
- The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells. | Oviedo-Boyso, J., et al. 2011. Infect Immun. 79: 4569-77. PMID: 21844240
- Reactive oxygen species and PI3K/Akt signaling in cancer. | Jin, SY., et al. 2014. Free Radic Biol Med. 75 Suppl 1: S34-5. PMID: 26461347
- Effects of the Akt inhibitor Src-homology 5 on proliferation and apoptosis of the laryngeal squamous cell carcinoma. | Jia, T., et al. 2018. J Cancer Res Ther. 14: 208-212. PMID: 29516987
Inhibitor of:
Akt, and Ser/Thr Protein Kinase.Activator of:
p38 α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH-5, 0.5 mg | sc-205973 | 0.5 mg | $154.00 | |||
SH-5, 1 mg | sc-205973A | 1 mg | $261.00 |