P311 Activators
P311 Activators are a series of chemical compounds that facilitate the enhancement of the protein P311 through discrete cellular and molecular mechanisms. Forskolin and IBMX, by increasing intracellular levels of cAMP, indirectly upregulate the activity of P311 through the activation of PKA and the inhibition of phosphodiesterases, respectively. These processes maintain an environment conducive to the signaling pathways P311 is involved in, thereby potentiating its function. PMA and Sphingosine-1-phosphate, through PKC activation and S1P receptor engagement, respectively, modify intracellular signaling networks that intersect with those of P311, suggesting a supportive role in the protein's activation. A23187, by altering intracellular calcium levels, triggers calcium-dependent pathways that could enhance P311's activity.
Furthermore, the use of ZnCl2, reflecting its role as a signaling molecule, may influence the activity of P311 by interacting with metalloproteinases that share signaling pathways with P311, thus potentially enhancing its functional role. Dibutyryl-cAMP, by acting asa cAMP analog, directly stimulates cAMP-dependent pathways, which is expected to support P311 activation due to the reliance of P311 on these pathways for its activity. Genistein's inhibition of tyrosine kinases could reduce competitive signaling, thereby allowing pathways involving P311 to be more pronounced.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and activate proteins within the same signaling pathway as P311, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This indirectly enhances P311 activity by sustaining the signaling cascade that involves cyclic nucleotide-dependent kinases. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate activates S1P receptors, which can engage intracellular signaling cascades that cross-talk with pathways P311 is involved in, thereby enhancing P311's activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate intermediates that participate in the signaling pathways of P311, potentially enhancing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which could activate calcium-dependent signaling pathways and enhance the activity of P311. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc chloride can act as a signaling molecule and may influence various signaling pathways, including those involving metalloproteinases that could interact with P311, thus enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it can enhance P311 activity via pathways that are regulated by cAMP levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor, by inhibiting these kinases, it could shift signaling through pathways that P311 is a part of, thereby enhancing P311 activity. | ||||||