OTTMUSG00000011268 Activators
Gm13275, a vital protein encoded by the gene of the same name, plays a pivotal role in cellular signaling and regulation. Its function encompasses diverse aspects of cellular physiology, making it an integral player in various signaling pathways within the cell. As a protein with multiple functions, Gm13275 is involved in the orchestration of critical cellular processes, contributing to the fine-tuning of cellular responses to external cues and environmental changes The primary function of Gm13275 lies in its ability to act as a molecular switch in cellular signaling pathways. It serves as a central hub for relaying extracellular signals to intracellular responses. Gm13275 is responsible for transmitting these signals through a series of intricate biochemical events, ultimately leading to the activation of specific cellular responses. Its significance is particularly notable in processes such as cell growth, differentiation, and survival, where it functions as a key mediator in pathways that regulate these fundamental aspects of cellular behavior.
The activation of Gm13275 involves a complex interplay of cellular events. Multiple factors, including receptor-ligand interactions and second messenger molecules, contribute to the activation process. Notably, Gm13275 can be directly activated by certain molecules that bind to it, initiating a cascade of phosphorylation events that culminate in its functional activation. Additionally, indirect activation mechanisms are also prevalent, where extracellular ligands interact with cell surface receptors, initiating signaling cascades that indirectly lead to the phosphorylation and activation of Gm13275. These intricate processes highlight the multifaceted nature of Gm13275's activation, reflecting its role as a central player in cellular signaling networks. In summary, Gm13275 is a versatile and indispensable protein with diverse functions in cellular signaling, and its activation mechanisms encompass a web of interactions and events that facilitate precise control over vital cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol activates Gm13275 by binding to the vitamin D receptor (VDR), leading to the formation of a VDR-retinoic acid X receptor (RXR) heterodimer. This complex then binds to vitamin D response elements (VDREs) in target genes, resulting in the transcription of genes involved in the activation of the target protein's signaling pathway, ultimately leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Gm13275 indirectly by activating protein kinase C (PKC). PKC activation triggers a downstream signaling cascade, ultimately leading to the phosphorylation and functional activation of the target protein. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
RA indirectly activates Gm13275 by modulating gene expression. It upregulates specific genes that encode proteins involved in the activation of the target protein's signaling pathway. This results in the functional activation of Gm13275 through the enhanced expression of pathway components. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Vitamin A indirectly activates Gm13275 by serving as a precursor for retinoic acid (RA) synthesis. RA, in turn, modulates gene expression to enhance the activity of the target protein's signaling pathway, leading to its functional activation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Gm13275 by depleting intracellular calcium stores. This leads to calcium release from the endoplasmic reticulum and activates calcium/calmodulin-dependent protein kinases (CaMK), which phosphorylate and activate the target protein, resulting in its functional activation. | ||||||
all-trans Retinal | 116-31-4 | sc-210778A sc-210778 | 250 mg 1 g | $129.00 $379.00 | 7 | |
all-trans Retinal indirectly activates Gm13275 by being converted to retinoic acid (RA) in cells. RA, as mentioned earlier, modulates gene expression to enhance the activity of the target protein's signaling pathway, ultimately resulting in its functional activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 indirectly activates Gm13275 by binding to its receptor EP4. EP4 receptor activation triggers intracellular signaling pathways, including the cAMP-PKA pathway, which can phosphorylate and activate the target protein, leading to its functional activation. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP directly activates Gm13275 by binding to and activating protein kinase A (PKA). Active PKA phosphorylates and activates the target protein, resulting in its functional activation. | ||||||