OTTMUSG00000008445 Inhibitors
The selected chemicals target various biochemical and cellular pathways that might influence the activity of the uncharacterized protein LOC381536. Cycloheximide, by inhibiting eukaryotic protein synthesis, can prevent the synthesis of LOC381536 at the ribosomal level. Rapamycin, targeting mTOR signaling, could indirectly influence LOC381536's synthesis or function, given mTOR's role in protein synthesis and cell growth. Staurosporine, as a broad kinase inhibitor, could affect kinase-dependent pathways potentially relevant to LOC381536. Bortezomib's inhibition of the proteasome may result in the accumulation of misfolded LOC381536, while Chloroquine's disruption of lysosomal function and autophagy could affect the degradation or post-translational modification of this protein. Wortmannin and LY294002, both PI3K inhibitors, could impact LOC381536 if it is involved in or regulated by the PI3K/Akt signaling pathway.
U0126 and PD98059, as inhibitors of the MEK component of the MAPK/ERK pathway, could indirectly inhibit LOC381536 if it is associated with cell signaling processes governed by this pathway. Curcumin, with its role in modulating inflammation and oxidative stress pathways, might influence LOC381536's function. SB203580, targeting p38 MAPK, could affect the protein in the context of stress-related signaling. Lastly, Z-VAD-FMK, a pan-caspase inhibitor, might indirectly inhibit LOC381536 through its role in apoptotic pathways. These inhibitors were selected based on the potential relevance of their target pathways to the uncharacterized protein LOC381536. Each chemical could potentially influence the function of LOC381536 by modulating key cellular processes or pathways in which this protein might be involved, although the specific role and mechanism of action of LOC381536 remain unknown.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step in protein elongation. This broad mechanism can inhibit LOC381536 by preventing its synthesis at the ribosomal level. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and protein synthesis. By impeding mTOR signaling, Rapamycin can indirectly inhibit the synthesis or function of proteins like LOC381536 involved in these pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor that can affect a wide range of kinases. It may inhibit LOC381536 by interfering with kinase-dependent pathways that could be relevant to the protein's function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, a complex responsible for degrading misfolded proteins. This could lead to an accumulation of misfolded LOC381536, indirectly inhibiting its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine disrupts lysosomal function and autophagy, processes that could be involved in the degradation or post-translational modification of proteins like LOC381536, thereby potentially inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By disrupting PI3K/Akt signaling, it could indirectly affect the function of LOC381536 if the protein is involved in or regulated by this pathway. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, another PI3K inhibitor, could similarly affect LOC381536 by inhibiting the PI3K/Akt pathway, potentially impacting proteins involved in related cellular processes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, part of the MAPK/ERK pathway. It could indirectly inhibit LOC381536 if the protein is involved in or regulated by this signaling pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known for its anti-inflammatory and antioxidant properties. It could inhibit LOC381536 by modulating pathways involved in inflammation or oxidative stress, which may affect the protein's function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059, an MEK inhibitor, could indirectly inhibit LOC381536 by affecting the MEK/ERK pathway, which is involved in cell signaling and might impact proteins associated with this pathway. | ||||||