ORMDL1 Inhibitors
ORMDL1 inhibitors are a diverse group of compounds that influence ORMDL1 activity or expression through various cellular pathways. This class includes kinase inhibitors like saracatinib and dasatinib, which target Src family kinases and potentially decrease phosphorylation levels of proteins involved in ORMDL1 regulation.
The class also includes inhibitors that modulate different signaling pathways, such as the MAPK/ERK pathway (e.g., U0126), JNK pathway (e.g., SP600125), PI3K/AKT pathway (e.g., LY294002, Wortmannin), and the mTOR pathway (e.g., Rapamycin). These inhibitors can change transcriptional and post-translational regulation of ORMDL1. Other members of this class, such as maraviroc, bortezomib, thapsigargin, and tunicamycin, influence ORMDL1 by altering the cellular environment or protein synthesis and degradation pathways
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $113.00 $1035.00 | 7 | |
Inhibits Src kinase, involved in regulating ORMDL1 activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Targets multiple tyrosine kinases, possibly reducing phosphorylation levels of proteins involved in ORMDL1 regulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, modifying transcription factors and potentially altering ORMDL1 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor, affecting AKT signaling pathways connected to ORMDL1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor, impacting AKT signaling and potentially influencing ORMDL1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor, modulating several pathways, potentially affecting ORMDL1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAP kinase inhibitor, might influence ORMDL1 through altering inflammatory response pathways. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor, affecting protein degradation pathways, indirectly impacting ORMDL1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
SERCA pump inhibitor, leading to altered calcium homeostasis, which might affect ORMDL1 function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibits N-linked glycosylation, potentially affecting proteins regulating ORMDL1. | ||||||