Date published: 2026-8-9

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Orexin Antibodies

Santa Cruz Biotechnology provides a broad selection of Orexin Antibodies for various research applications. Orexin Antibodies are compatible with western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Orexins, also known as hypocretins, are neuropeptides that play a crucial role in regulating arousal, wakefulness, and appetite. They are primarily produced in the hypothalamus and are essential for maintaining energy balance and sleep-wake cycles. Dysregulation of orexin signaling has been implicated in various sleep disorders, including narcolepsy. Understanding orexin function is vital for developing therapeutic strategies for sleep-related conditions. Research into orexin signaling pathways continues to reveal new insights about sleep regulation and metabolic processes. The high specificity of monoclonal orexin antibodies from Santa Cruz Biotechnology enables researchers to advance scientific understanding of sleep disorders and potential therapeutic interventions.

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Orexin Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Orexin R-1/2 Antibody (E-9)

sc-166111mouse IgG1 κ126-425 (h)WB, IP, IF, ELISAh
5
(1)

Orexin-A Antibody (KK09)

sc-80263mouse IgG1 κ34-66 (h)WB, IP, IF, IHC(P)m, r, h
22
(4)

Orexin siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

Orexin-A/B siRNA (h)

sc-42152hGene SilencingN/A0
(0)

Orexin-A/B shRNA Plasmid (h)

sc-42152-SHhGene SilencingPuromycin0
(0)

Orexin-A/B shRNA (h) Lentiviral Particles

sc-42152-VhGene SilencingPuromycin0
(0)

Orexin-A/B siRNA (m)

sc-42153mGene SilencingN/A0
(0)

Orexin-A/B shRNA Plasmid (m)

sc-42153-SHmGene SilencingPuromycin0
(0)

Orexin-A/B shRNA (m) Lentiviral Particles

sc-42153-VmGene SilencingPuromycin0
(0)

Orexin R-1 siRNA (h)

sc-36131hGene SilencingN/A0
(0)

Orexin R-1 shRNA Plasmid (h)

sc-36131-SHhGene SilencingPuromycin0
(0)

Orexin R-1 shRNA (h) Lentiviral Particles

sc-36131-VhGene SilencingPuromycin0
(0)

Orexin R-1 siRNA (m)

sc-36132mGene SilencingN/A0
(0)

Orexin R-1 shRNA Plasmid (m)

sc-36132-SHmGene SilencingPuromycin0
(0)

Orexin R-1 shRNA (m) Lentiviral Particles

sc-36132-VmGene SilencingPuromycin0
(0)

Orexin R-1 siRNA (r)

sc-61898rGene SilencingN/A0
(0)

Orexin R-1 shRNA Plasmid (r)

sc-61898-SHrGene SilencingPuromycin0
(0)

Orexin R-1 shRNA (r) Lentiviral Particles

sc-61898-VrGene SilencingPuromycin0
(0)

Orexin R-2 siRNA (h)

sc-36133hGene SilencingN/A0
(0)

Orexin R-2 shRNA Plasmid (h)

sc-36133-SHhGene SilencingPuromycin0
(0)

Orexin R-2 shRNA (h) Lentiviral Particles

sc-36133-VhGene SilencingPuromycin0
(0)

Orexin R-2 siRNA (m)

sc-36134mGene SilencingN/A0
(0)

Orexin R-2 shRNA Plasmid (m)

sc-36134-SHmGene SilencingPuromycin0
(0)

Orexin R-2 shRNA (m) Lentiviral Particles

sc-36134-VmGene SilencingPuromycin0
(0)

Orexin CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Orexin-A CRISPR/Cas9 KO Plasmid (h)

sc-400357Gene Knockouth0
(0)

Orexin-A/B CRISPR/Cas9 KO Plasmid (m)

sc-420816Gene Knockoutm0
(0)

Orexin CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Orexin-A Double Nickase Plasmid (h)

sc-400357-NICGene Knockouth0
(0)

Orexin-A Double Nickase Plasmid (h2)

sc-400357-NIC-2Gene Knockouth0
(0)

Orexin R-2 Double Nickase Plasmid (h)

sc-402343-NICGene Knockouth0
(0)

Orexin R-2 Double Nickase Plasmid (h2)

sc-402343-NIC-2Gene Knockouth0
(0)

Orexin CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

Orexin-A CRISPR Activation Plasmid (h)

sc-400357-ACTGene Activationh0
(0)

Orexin R-1 CRISPR Activation Plasmid (h)

sc-401613-ACTGene Activationh0
(0)

Orexin R-2 CRISPR Activation Plasmid (h)

sc-402343-ACTGene Activationh0
(0)