OR8H2 Activators
OR8H2 encompass a diverse array of compounds that engage the olfactory receptor through a direct and specific interaction, initiating a cascade of cellular signaling events responsible for the perception of smell. Among these activators, 1-Octanol, Geranyl acetate, and Citronellol are exemplary in their ability to bind to the receptor, which is embedded in the membrane of olfactory sensory neurons. Upon binding, these chemicals induce a conformational change in OR8H2. This structural alteration facilitates the coupling of the receptor to its associated G-proteins, which then undergo a GDP to GTP exchange on their alpha subunit, effectively becoming activated. Subsequent dissociation of the G-protein subunits leads to the activation of downstream effectors, such as adenylate cyclase, which catalyzes the conversion of ATP to the second messenger cAMP. The accumulation of cAMP opens ion channels that allow the influx of ions such as calcium and sodium, leading to depolarization of the neuron and initiation of an action potential that propagates the olfactory signal to the brain.
Benzyl acetate, Phenethyl alcohol, Alpha-Pinene, Eugenol, Linalool, Isoamyl acetate, Methyl anthranilate, Beta-Caryophyllene, and Limonene each engage with OR8H2 through a similar mechanistic pathway. Their binding to OR8H2's specialized sites ensures a broad spectrum of scent detection. The activation of the receptor by these compounds results in a similar G-protein-coupled receptor pathway engagement, leading to the generation of action potentials that are relayed to the olfactory cortex. The specificity of the interaction between OR8H2 and these diverse molecules underlies the intricate selectivity of odorant molecules, allowing for the fine discrimination of a vast array of scents by the olfactory system. This intricate mechanism of activation and signal transduction by various chemical activators underscores the complexity and precision of the olfactory system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $46.00 | ||
1-Octanol, being an odorant molecule, is known to activate olfactory receptors such as OR8H2 by binding directly to the receptor, inducing a conformational change that leads to signal transduction and the activation of downstream G-protein pathways, resulting in olfactory perception. | ||||||
Geranyl acetate | 105-87-3 | sc-235243 | 25 g | $41.00 | ||
Geranyl acetate can specifically bind and activate certain olfactory receptors, including OR8H2, by interacting with the binding site of the protein, causing activation of the G-protein coupled receptor mechanism and subsequent cellular responses linked to olfaction. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol has the potential to activate OR8H2 as it is a volatile terpene alcohol that can bind to olfactory receptors, triggering the G-protein coupled receptor pathway and resulting in the activation of the sensory signal transduction cascade involved in smell. | ||||||
Benzyl acetate | 140-11-4 | sc-252427 | 100 g | $30.00 | 1 | |
As an aromatic ester, Benzyl acetate is capable of activating olfactory receptors including OR8H2 by binding to its specific site on the receptor, inducing activation of the receptor's associated G-protein signaling pathways involved in the sensory perception of fragrance. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol is known to activate olfactory receptors by binding to specific sites on proteins like OR8H2, leading to receptor conformational changes, activation of G-protein coupled signal transduction, and initiation of olfactory sensory signaling. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-Pinene can activate OR8H2 through its interaction with the binding site on the olfactory receptor, initiating the activation of the G-protein coupled receptor pathway and thus activating the olfactory sensory neuron signal transduction cascade. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a phenylpropene, is known to activate olfactory receptors such as OR8H2 by binding to the receptor's active site, enabling the activation of G-protein coupled receptor signaling pathways that lead to the perception of smell. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $47.00 $72.00 $110.00 | ||
Linalool acts as an activator of olfactory receptors like OR8H2 by binding to its ligand-binding site, which triggers the activation of G-protein coupled receptor mechanisms and subsequent sensory signal transduction processes. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is capable of activating OR8H2 as it can bind to the olfactory receptor and activate the G-protein coupled receptor pathway, facilitating the transduction of signals that contribute to the sense of smell. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
Beta-Caryophyllene has the potential to activate the OR8H2 receptor by direct binding, which leads to activation of the G-protein coupled receptor pathway, triggering the olfactory signal transduction process. | ||||||