OR8B4 Activators
OR8B4 include a variety of compounds commonly found in fragrant plants and used in flavorings and perfumery. These molecules, such as citronellal, eugenol, geraniol, methyl salicylate, β-ionone, phenethyl alcohol, limonene, benzaldehyde, hexanal, α-pinene, linalool, and isoamyl acetate, are known to interact with and activate olfactory receptors. When these chemicals bind to OR8B4, a signaling cascade is initiated. This cascade begins with the replacement of GDP with GTP on the G-protein coupled to the receptor, leading to the activation of adenylate cyclase, which then increases the levels of cAMP within the cell. This increase in cAMP can activate various downstream signaling pathways, ultimately leading to cellular responses that translate into the perception of smell.
Each of these ligands can bind to OR8B4 at its specific binding site, which is typically tuned to the molecular shape and functional groups of the odorant molecule. Upon binding, a conformational change occurs in OR8B4 that triggers the associated G-protein to exchange GDP for GTP, activating it. The activated G-protein then dissociates into subunits which interact with adenylate cyclase, catalyzing the conversion of ATP to cAMP. The rise in cAMP opens ion channels, particularly calcium channels, leading to an influx of calcium ions. This ion exchange generates an electrical signal which propagates along the olfactory neurons and is eventually processed in the brain as a distinct odor. The process is terminated when the GTP on the G-protein is hydrolyzed to GDP, returning the G-protein to its inactive state, and the cAMP levels are reduced by phosphodiesterases, which helps reset the receptor for another activation event.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is known to be an agonist for olfactory receptors, and assuming OR8B4 is an olfactory receptor, citronellal binding could lead to activation of OR8B4, triggering the G-protein coupled receptor pathway and leading to an increase in intracellular cAMP, which activates the protein. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol activates certain olfactory receptors, which suggests that if OR8B4 is an olfactory receptor, eugenol could bind directly to OR8B4, leading to the activation of the protein via the olfactory signaling cascade. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol is known to activate olfactory receptors, and if OR8B4 is an olfactory receptor, geraniol can bind to and activate OR8B4, initiating a signal transduction pathway that results in protein activation. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate is recognized by olfactory receptors, and given OR8B4 is an olfactory receptor, this compound could activate OR8B4 by binding to it, thereby starting a signaling cascade that activates the protein. | ||||||
beta-Ionone | 14901-07-6 | sc-291976 | 25 ml | $83.00 | ||
β-Ionone is another olfactory receptor agonist, and if OR8B4 is in this class, it may be activated upon binding of β-ionone, leading to the activation of downstream G-protein signaling pathways associated with the protein. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $68.00 | ||
2-Phenylethanol has been identified as an activator for some olfactory receptors. Binding of this compound to OR8B4, if it is an olfactory receptor, would activate the receptor and its associated protein signaling pathways. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
Limonene is known to bind and activate certain olfactory receptors. Upon binding to OR8B4, limonene could activate the protein by triggering the olfactory signal transduction mechanisms. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal is a known activator of certain olfactory receptors. If OR8B4 is an olfactory receptor, hexanal could bind and activate the protein through the canonical olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $51.00 $113.00 | 2 | |
α-Pinene activates specific olfactory receptors. By binding to OR8B4, if it is an olfactory receptor, α-pinene could activate the protein via the associated G-protein signaling cascade. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool is known to activate olfactory receptors. Binding of linalool to OR8B4, assuming OR8B4 is an olfactory receptor, would lead to activation of the protein through the olfactory signal transduction pathway. | ||||||