OR52E4 Inhibitors
OR52E4 inhibitors belong to a class of chemical compounds that interact specifically with the OR52E4 receptor, which is part of the olfactory receptor (OR) family. These receptors are primarily involved in detecting and binding odorant molecules, playing a central role in the sense of smell. OR52E4 is a G protein-coupled receptor (GPCR), a type of receptor that transmits signals across cellular membranes through the binding of extracellular molecules, leading to intracellular responses. Inhibitors of OR52E4 function by obstructing the binding of specific ligands to this receptor, preventing its activation and subsequent signal transduction. The inhibition mechanism often involves either competitive binding, where the inhibitor competes with the natural ligand for the receptor site, or allosteric modulation, where the inhibitor binds to a site distinct from the ligand-binding pocket, altering receptor conformation and reducing its functional activity.
The study of OR52E4 inhibitors contributes to a broader understanding of GPCR modulation, a crucial aspect of chemical signal transduction research. By inhibiting specific olfactory receptors like OR52E4, researchers can decipher receptor-ligand interaction mechanisms, receptor specificity, and the structural aspects that govern signal activation in olfactory neurons. These inhibitors also serve as valuable tools in the investigation of olfactory pathways, helping to map out how the activation or suppression of specific receptors correlates with downstream signaling cascades within cellular systems. Such studies contribute to advancing knowledge in receptor biology, structure-activity relationships, and the dynamics of GPCR function across various physiological processes, without involving any clinical or pharmaceutical considerations.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor can lead to hyperacetylation of histones, potentially resulting in the downregulation of OR52E4 by altering the accessibility of its promoter region to transcriptional repressors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could induce hypomethylation of the OR52E4 gene promoter. While this often leads to gene activation, in some contexts, it could disrupt binding sites for transcriptional activators, thereby reducing OR52E4 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich DNA sequences, Mithramycin A may displace transcriptional activators from the OR52E4 promoter or prevent their binding, resulting in decreased transcription of the OR52E4 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to downregulate the expression of specific genes by inhibiting NF-kB, a transcription factor that might be enhancing OR52E4 expression, leading to a decrease in OR52E4 mRNA levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Known for its mTOR inhibition properties, Sirolimus could reduce OR52E4 expression by decreasing the overall rate of translation within cells, which would affect the synthesis of the OR52E4 protein. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can raise endosomal pH and potentially disrupt the trafficking of the OR52E4 protein to the cell surface, reducing its functional expression and possibly leading to lower overall OR52E4 levels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This glucocorticoid can repress OR52E4 expression by binding to glucocorticoid response elements in the OR52E4 gene′s regulatory regions, leading to transcriptional repression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As an activator of retinoic acid receptors, retinoic acid could downregulate OR52E4 by binding to these receptors and altering the transcriptional activity of genes including OR52E4. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This antibiotic intercalates into DNA, preventing the advancement of RNA polymerase along the DNA template, which would lead to a decrease in OR52E4 mRNA synthesis. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
As an inhibitor of FGFR kinases, PD173074 could reduce the expression of OR52E4 by inhibiting downstream signaling pathways that provide necessary signals for OR52E4 gene transcription. | ||||||