OR52E4 Activators
OR52E4 include a variety of aromatic compounds that engage the olfactory receptors through specific molecular interactions. Isoamyl acetate, benzaldehyde, eugenol, phenethyl alcohol, methyl salicylate, citronellol, limonene, geraniol, anethole, ethyl vanillin, cinnamaldehyde, and linalool are all capable of binding to the ligand site of OR52E4. Upon binding, these chemicals induce conformational changes in the structure of OR52E4. This conformational shift is crucial as it triggers the G-protein coupled receptor (GPCR) signaling pathway. The activation of OR52E4 by these compounds leads to the initiation of a cascade of intracellular events that result in the transmission of olfactory information to the brain, where it is perceived as distinct scents.
The process begins when one of the aforementioned chemicals enters the nasal cavity and binds to OR52E4 located on the membrane of olfactory sensory neurons. Isoamyl acetate's interaction with OR52E4, for instance, sets off a signal transduction pathway as it fits into the ligand-binding domain of the receptor. Similarly, benzaldehyde and eugenol, with their characteristic almond and clove scents respectively, activate OR52E4 by engaging with the receptor in a lock-and-key manner. Floral and fruity scents like those of phenethyl alcohol and methyl salicylate also activate OR52E4, further emphasizing the versatility of this receptor in detecting a wide array of odor molecules. Citronellol and limonene, with their fresh lemon and citrus notes, engage with OR52E4 in a comparable fashion. Geraniol, anethole, and ethyl vanillin, despite their varied structures, are similarly adept at activating OR52E4, leading to the perception of their respective rose, anise, and vanilla scents. Lastly, cinnamaldehyde and linalool, known for their warm cinnamon and delicate floral aromas, complete the spectrum of OR52E4 activators by binding to the receptor and facilitating the olfactory signal transduction process. Each chemical, upon binding to OR52E4, plays a part in the complex and nuanced detection of odors that the human olfactory system is capable of discerning.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isoamyl acetate is known to activate olfactory receptors, and while specific data on OR52E4 might not be available, it stands to reason that as a volatile compound, it could activate OR52E4 by binding to its ligand site, thereby triggering the olfactory signaling cascade leading to sensory neuron stimulation. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a component of clove oil, activates certain olfactory receptors. Given its chemical structure, it could activate OR52E4 through direct interaction with the ligand-binding domain, activating the G-protein coupled receptor pathway. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol is known for its floral scent and activates olfactory receptors. It may activate OR52E4 by direct interaction, leading to conformational changes in the protein and initiation of the olfactory signal transduction process. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, often associated with the scent of wintergreen, may activate OR52E4 by binding to its ligand-binding site, which would then activate the olfactory signal transduction pathway. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $32.00 $156.00 | ||
Citronellol is a scent compound that may activate OR52E4 by binding directly to the receptor, triggering a G-protein coupled response and subsequent signal transduction in olfactory sensory neurons. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, a citrus scent compound, could activate OR52E4 by interacting with the ligand-binding domain of the receptor, leading to activation of the G-protein coupled receptor signaling pathway. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a common floral scent compound, could activate OR52E4 by direct binding, leading to the activation of the olfactory G-protein coupled receptor pathway and signal transduction in olfactory neurons. | ||||||
Anethole | 104-46-1 | sc-481571A sc-481571 | 10 g 100 g | $576.00 $316.00 | ||
Anethole is a flavor compound that activates certain olfactory receptors. It may activate OR52E4 by binding to the receptor's ligand-binding domain directly, which would activate the downstream G-protein coupled signaling cascade. | ||||||
3-Ethoxy-4-hydroxybenzaldehyde | 121-32-4 | sc-238538 | 100 g | $31.00 | ||
3-Ethoxy-4-hydroxybenzaldehyde, known for a vanilla-like scent, could activate OR52E4 by binding directly to the receptor, causing an activation of the G-protein coupled receptor pathway involved in olfactory perception. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde, associated with cinnamon aroma, could activate OR52E4 by directly interacting with its ligand site, leading to activation of the olfactory signaling pathway through G-protein coupled receptor mechanisms. | ||||||