OR52B4 Activators
OR52B4 can interact with the ligand-binding site of this G-protein coupled receptor (GPCR), which can lead to a series of intracellular signaling events. Isoamylamine, for instance, is a volatile amine that can activate OR52B4 by binding to its ligand-binding site. This interaction can induce a conformational change in the receptor, which is necessary for the initiation of the signaling cascade. Similarly, eugenol, a phenolic compound found in essential oils, can activate the receptor through similar binding interactions. The specificity of the interaction comes from the unique structural complementarity between eugenol and the ligand-binding domain of OR52B4. This can trigger a change in the receptor's conformation, leading to the activation of the downstream signaling molecules.
Other chemicals such as heptanal, citral, and phenethyl alcohol can also activate OR52B4 through their binding to the receptor. Heptanal, an aldehyde, can interact with the receptor and prompt a conformational change that can activate the associated G-proteins. Citral, a terpenoid with a lemon scent, can bind to specific regions on OR52B4, causing conformational changes that can result in the activation of the G-protein coupled receptor signaling pathway. Phenethyl alcohol, commonly found in floral fragrances, can activate OR52B4 by interacting with its odorant-binding site. This interaction can lead to a cascade of intracellular events through G-protein activation. Benzaldehyde, hexyl acetate, limonene, methyl anthranilate, geraniol, alpha-ionone, and beta-caryophyllene can all similarly activate OR52B4 by binding to the receptor's ligand-binding domain, leading to a series of intracellular responses that are characteristic of GPCR signaling pathways. Each of these chemicals has a structure that can fit into the ligand-binding domain of OR52B4, which can enable them to act as effective activators of this olfactory receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3-Methyl-1-butanol | 123-51-3 | sc-231818 sc-231818A | 500 ml 1 L | $71.00 $95.00 | ||
As OR52B4 is an olfactory receptor, isoamylamine, a volatile amine, is known to be detected by olfactory receptors and could therefore activate OR52B4 by binding to its ligand-binding site and initiating a signal transduction cascade. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol, a phenolic compound found in essential oils, is known to activate olfactory receptors by interacting with specific binding sites, which could lead to the activation of OR52B4 through conformational changes that trigger signal transduction pathways. | ||||||
Heptaldehyde | 111-71-7 | sc-250089 sc-250089A | 2 ml 100 ml | $30.00 $59.00 | ||
Heptanal is an aldehyde with the potential to activate olfactory receptors including OR52B4 through binding interactions that change receptor conformation and activate associated G-proteins, leading to signal transduction. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a terpenoid found in lemon scent, could specifically activate OR52B4 by binding to its ligand-specific region, causing conformational changes that activate the G-protein coupled receptor signaling pathway. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol, found in floral fragrances, is known to activate olfactory receptors. It could activate OR52B4 by binding to its odorant-binding site, initiating a cascade of intracellular events through G-protein activation. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl acetate, known for its fruity odor, could activate OR52B4 by interacting with the binding site on the receptor, which in turn activates the G-protein signaling cascade. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
Limonene, a common terpene with a citrus scent, could activate OR52B4 by binding to specific sites on the receptor, causing a conformational change and activating the G-protein coupled signaling mechanism. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $45.00 $119.00 | ||
Geraniol, a monoterpenoid with a rose-like scent, could activate OR52B4 by interacting with the receptor's binding site, causing a conformational change that triggers the activation of the signal transduction cascade. | ||||||
α-Ionone | 127-41-3 | sc-239157 | 100 g | $75.00 | ||
Alpha-ionone, a fragrance compound with a violet-like scent, could activate OR52B4 by binding to the receptor and causing a conformational alteration that leads to the activation of the G-protein signaling pathway. | ||||||
(−)-trans-Caryophyllene | 87-44-5 | sc-251281 sc-251281A sc-251281B sc-251281C | 1 ml 5 ml 25 ml 1 L | $81.00 $160.00 $446.00 $2918.00 | 1 | |
Beta-caryophyllene, a sesquiterpene found in essential oils, could activate OR52B4 by binding to the receptor's ligand-specific site and inducing a conformational change that activates the G-protein coupled signaling pathway. | ||||||