OR4F17 Activators
Olfactory receptor OR4F17, as a member of the G-protein-coupled receptor (GPCR) family, functions primarily through adenylate cyclase activation, culminating in cAMP accumulation. This accumulation is pivotal as it activates cyclic nucleotide-gated channels, leading to cellular depolarization and the inception of odorant perception. Chemical agents that can modulate this cascade serve as effective activators for OR4F17. One prevalent class of these agents is the β-adrenergic agonists, such as Isoproterenol, Epinephrine, Albuterol, and Fenoterol. Their function hinges on stimulating adenylate cyclase through β-adrenergic receptors, subsequently increasing intracellular cAMP levels. With elevated cAMP, the cyclic nucleotide-gated channels associated with olfactory receptors like OR4F17 are activated, leading to the receptor's functional modulation.
Another key set of agents that wield influence on the OR4F17 cascade are Phosphodiesterase (PDE), exemplified by Rolipram. By cAMP breakdown, these effectively amplify cAMP levels in the cell, providing a conducive environment for the activation of OR4F17-associated cyclic nucleotide-gated channels. Furthermore, neurotransmitters such as Dopamine and Norepinephrine, by interacting with their respective GPCRs, can elevate adenylate cyclase activity, thus enriching the cAMP pool. The subsequent increased cAMP serves as a crucial modulator for the cyclic nucleotide-gated channels in olfactory receptors, steering the functional activity of receptors like OR4F17. Collectively, understanding these chemicals and their precise modulatory mechanisms is instrumental in comprehending the broader landscape of OR4F17 activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective β-adrenergic agonist that activates adenylate cyclase to increase intracellular cAMP levels. Elevated cAMP can activate cyclic nucleotide-gated channels associated with olfactory receptors such as OR4F17. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, an endogenous catecholamine, stimulates both α and β-adrenergic receptors. Its action on β-adrenergic receptors activates adenylate cyclase, raising cAMP levels and potentially impacting olfactory receptors like OR4F17. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, as a neurotransmitter, binds to its receptors, which are GPCRs. By stimulating specific dopamine receptors, it can elevate adenylate cyclase activity, leading to increased cAMP, influencing the function of olfactory receptors. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective PDE4 inhibitor that prevents the breakdown of cAMP. Increased cAMP levels can modulate the cyclic nucleotide-gated channels in olfactory receptors, potentially influencing the function of receptors like OR4F17. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine interacts with α and β-adrenergic receptors. Its action on the latter stimulates adenylate cyclase, elevating cAMP levels, potentially affecting olfactory receptors like OR4F17 by modulating cyclic nucleotide-gated channels. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Albuterol is a β2-adrenergic agonist that stimulates adenylate cyclase, resulting in increased cAMP. The subsequent elevated cAMP can influence the cyclic nucleotide-gated channels of olfactory receptors such as OR4F17. | ||||||
Formoterol | 73573-87-2 | sc-337847 | 100 mg | $571.00 | ||
Formoterol, another β2-adrenergic agonist, can stimulate adenylate cyclase, leading to elevated cAMP levels. The enhanced cAMP can potentially impact the cyclic nucleotide-gated channels of olfactory receptors like OR4F17. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Salmeterol, a long-acting β2-adrenergic agonist, activates adenylate cyclase, raising cAMP levels. The increased cAMP can modulate cyclic nucleotide-gated channels, influencing the activity of olfactory receptors such as OR4F17. | ||||||
Indacaterol Maleic Acid Salt | 753498-25-8 | sc-483888 | 1 g | $555.00 | ||
Indacaterol, a ultra-long-acting β2-adrenergic agonist, stimulates adenylate cyclase, resulting in elevated cAMP levels. This cAMP can potentially influence the cyclic nucleotide-gated channels of olfactory receptors, impacting the function of OR4F17. | ||||||