Date published: 2025-12-24

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OR4C6 Inhibitors

OR4C6 inhibitors consist of a diverse set of chemicals that interfere with various signaling pathways potentially related to the activity of OR4C6, a G protein-coupled receptor (GPCR). Haloperidol and spiperone, both D2 receptor antagonists, decrease cAMP levels by inhibiting adenylyl cyclase, which could indirectly inhibit OR4C6 if it signals through cAMP. U73122, by inhibiting PLC, and ritanserin, throughblocking 5-HT2 receptors, both prevent the formation of DAG and IP3, which are crucial for the activation of PKC and the release of intracellular calcium stores. These actions could lead to the inhibition of OR4C6 if it is involved in the PLC pathway. Rauwolscine, by antagonizing α2-adrenergic receptors, potentially inhibits OR4C6 by increasing the release of neurotransmitters that may negatively modulate OR4C6 signaling. Losartan, as an AT1 antagonist, blocks the effects of angiotensin II, which could influence OR4C6 activity if it is intertwined with angiotensin II-mediated signaling. Furthermore, forskolin, despite its role in directly activating adenylyl cyclase, can result in the inhibition of OR4C6 if OR4C6 is part of a cAMP-mediated negative feedback mechanism. Clozapine, through its broad receptor antagonism, could decrease cAMP levels indirectly, thereby suppressing OR4C6 activity if it relies on cAMP. PD98059 disrupts the MAPK/ERK pathway by inhibiting MEK, and this interruption could extend to OR4C6 if there is a regulatory connection between OR4C6 and this pathway. Verapamil and BAPTA-AM both act on calcium signaling, with verapamil inhibiting calcium influx and BAPTA-AM chelating intracellular calcium. If OR4C6 is calcium-dependent, these compounds would inhibit its signaling. Y-27632, by inhibiting ROCK, affects cytoskeletal rearrangement, which could lead to the inhibition of OR4C6 if its signaling is related to cytoskeletal dynamics.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$50.00
$128.00
(0)

Lidocaine is a sodium channel blocker that impedes neuronal action potential propagation. If OR4C6 is a neuronal protein that relies on action potential-mediated signaling for its activity, lidocaine would inhibit OR4C6 by preventing the initiation or propagation of action potentials.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin is an mTOR inhibitor and could inhibit OR4C6 if OR4C6 is involved in pathways regulated by mTOR, such as growth, proliferation, and survival pathways.

Haloperidol

52-86-8sc-507512
5 g
$190.00
(0)

Haloperidol is a dopamine receptor antagonist that can inhibit dopamine signaling. If OR4C6 is part of a dopamine-dependent signaling pathway, haloperidol would inhibit OR4C6 activity by blocking dopamine receptors.

Verapamil

52-53-9sc-507373
1 g
$367.00
(0)

Verapamil is an L-type calcium channel blocker. It inhibits the influx of calcium ions, which are vital for various cellular processes. If OR4C6 requires calcium-mediated signaling for its activity, verapamil would inhibit it by blocking these channels.

Dantrolene

7261-97-4sc-500165
25 mg
$350.00
7
(0)

Dantrolene inhibits ryanodine receptors on the sarcoplasmic reticulum, which are involved in calcium release. If OR4C6 is activated by intracellular calcium release, dantrolene would inhibit OR4C6 by reducing calcium availability.

Amiloride • HCl

2016-88-8sc-3578
sc-3578A
25 mg
100 mg
$22.00
$56.00
6
(2)

Amiloride is a diuretic that acts as a sodium-proton exchanger blocker and also inhibits certain sodium channels. Its action on sodium homeostasis could inhibit OR4C6 if OR4C6 activity is sodium-dependent.

Losartan

114798-26-4sc-353662
100 mg
$127.00
18
(1)

Losartan is an angiotensin II receptor blocker, which would inhibit OR4C6 if OR4C6 activity is modulated by angiotensin II receptor signaling pathways.

Diazoxide

364-98-7sc-200980
1 g
$300.00
5
(1)

Diazoxide opens ATP-sensitive potassium channels, leading to membrane hyperpolarization. If OR4C6 activity is linked to membrane potential or potassium channel activity, diazoxide would inhibit OR4C6 by stabilizing the membrane in a hyperpolarized state.

Ondansetron

99614-02-5sc-201127
sc-201127A
10 mg
50 mg
$80.00
$326.00
1
(0)

Ondansetron is a selective serotonin 5-HT3 receptor antagonist. If OR4C6 is involved in serotonin signaling pathways, ondansetron would lead to OR4C6 inhibition by blocking these receptors.