OR4C16 Inhibitors
OR4C16 inhibitors encompass a variety of chemical compounds that indirectly affect the signaling pathways and cellular processes upon which OR4C16 relies. Brefeldin A, through its inhibitory action on ARF, leads to a disassembly of the Golgi structure, consequently impairing the trafficking of OR4C16 to the cell surface where it would normally function in signal transduction. Monensin's disruption of ion gradients is crucial for the proper conformation and function of OR4C16, as the receptor's activity is sensitive to the ionic environment. Both Go 6983 and Chelerythrine Chloride inhibit PKC, which is instrumental in the phosphorylation of proteins that interact with GPCRs, thus potentially reducing the efficacy of OR4C16 signaling.
The sequence of signaling events necessary for OR4C16 to exert its effects can be influenced by compounds such as NF449 and Pertussis Toxin, which target G protein subunits. NF449's inhibition of Gαs reduces the receptor's ability to activate its associated G protein, and Pertussis Toxin impairs Gi/o proteins, potentially impeding OR4C16's signal transduction. Inhibitors like PD 98059 and SB 203580 target the MAPK pathway, which can impinge on the phosphorylation and, hence, the activity of proteins that are pivotal for OR4C16 function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), Brefeldin A disrupts the Golgi apparatus structure and inhibits protein transport to the cell membrane. This would prevent OR4C16 from being transported to the cell surface, thus inhibiting its sensory function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
A carboxylic ionophore that disrupts intracellular ion gradients by transporting ions across cell membranes. Monensin's alteration of cellular ion homeostasis can affect OR4C16's conformation and signaling ability. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
A potent protein kinase C (PKC) inhibitor which may inhibit the phosphorylation of proteins involved in GPCR signaling, leading to reduced OR4C16 signaling due to lack of requisite phosphorylation events. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
This compound is a selective inhibitor of PKC, which is involved in GPCR signaling pathways. Inhibition of PKC can downregulate signaling cascades that are essential for OR4C16 function. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
A potent and selective inhibitor of the Gαs subunit of G proteins. By inhibiting Gαs, NF449 would prevent OR4C16 from activating its associated G protein, thus reducing its signaling capability. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
It selectively targets Gi/o proteins, preventing their interaction with GPCRs like OR4C16, which could rely on Gi/o for signal transduction and thereby inhibiting OR4C16 signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK, which is upstream of ERK in the MAPK pathway. This inhibition can reduce the phosphorylation of proteins that may be necessary for OR4C16's functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A specific inhibitor of p38 MAP kinase, potentially reducing the phosphorylation of downstream targets that could be important for OR4C16 signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor, which affects the actin cytoskeleton. This would influence the trafficking and cell surface expression of OR4C16, potentially reducing its signaling ability. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that may reduce phosphorylation events necessary for OR4C16 signaling, leading to reduced receptor activity. | ||||||